FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1581248598> ?p ?o ?g. }

• W1581248598 endingPage "238" @default.
• W1581248598 startingPage "230" @default.
• W1581248598 abstract "Epithelial-mesenchymal transition (EMT) is a complex biological program during which cells loss epithelial phenotype and acquire mesenchymal features. EMT is thought to be involved in the pathogenesis of various fibrotic diseases including pulmonary fibrosis (PF). Recent studies suggest that endoplasmic reticulum (ER) stress is associated with EMT in the progression of PF. However, the exact mechanism is unclear. Here, we developed a PF model with bleomycin (BLM) administration in rats and conducted several simulation experiments in alveolar epithelial cell (AECs) RLE-6TN to unravel the role of inositol-requiring protein 1 (IRE1) - X-box-binding protein 1 (XBP1) signal pathway in ER stress-induced EMT in PF. First, we observed that ER stress was occurred in type II AECs accompanied by EMT in BLM-induced PF. Then we explored the role of IRE1-XBP1-snail pathway in transforming growth factor (TGF)-β1/tunicamycin (TM)-induced EMT. When TGF-β1/TM was treated on AECs, IRE1 and XBP1 were overexpressed, meanwhile, snail expression was upregulated accompanied with EMT. However, when IRE1 or XBP1 was knockdown, TGF-β1/TM-induced EMT were blocked while the expression of snail was inhibited. Then we silenced snail and found that TGF-β1/TM-induced EMT were also suppressed, but it had no effect on the up-regulated expression of IRE1 and XBP1. Thus, we concluded that IRE1-XBP1 pathway promotes EMT via mediating snail expression in PF." @default.
• W1581248598 created "2016-06-24" @default.
• W1581248598 creator A5005087327 @default.
• W1581248598 creator A5029437943 @default.
• W1581248598 creator A5032205498 @default.
• W1581248598 creator A5032538286 @default.
• W1581248598 creator A5037474461 @default.
• W1581248598 creator A5050912249 @default.
• W1581248598 creator A5052708012 @default.
• W1581248598 creator A5087055576 @default.
• W1581248598 date "2015-08-01" @default.
• W1581248598 modified "2023-10-16" @default.
• W1581248598 title "Inositol-requiring protein 1 – X-box-binding protein 1 pathway promotes epithelial–mesenchymal transition via mediating snail expression in pulmonary fibrosis" @default.
• W1581248598 cites W1503066105 @default.
• W1581248598 cites W1530495975 @default.
• W1581248598 cites W1970266620 @default.
• W1581248598 cites W1972500796 @default.
• W1581248598 cites W1973400283 @default.
• W1581248598 cites W1981894899 @default.
• W1581248598 cites W1989970963 @default.
• W1581248598 cites W1991867884 @default.
• W1581248598 cites W1998079027 @default.
• W1581248598 cites W2013996883 @default.
• W1581248598 cites W2037643149 @default.
• W1581248598 cites W2127031103 @default.
• W1581248598 cites W2162695817 @default.
• W1581248598 cites W2166696251 @default.
• W1581248598 cites W2169445756 @default.
• W1581248598 cites W4242987271 @default.
• W1581248598 doi "https://doi.org/10.1016/j.biocel.2015.06.006" @default.
• W1581248598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26065400" @default.
• W1581248598 hasPublicationYear "2015" @default.
• W1581248598 type Work @default.
• W1581248598 sameAs 1581248598 @default.
• W1581248598 citedByCount "24" @default.
• W1581248598 countsByYear W15812485982016 @default.
• W1581248598 countsByYear W15812485982017 @default.
• W1581248598 countsByYear W15812485982018 @default.
• W1581248598 countsByYear W15812485982019 @default.
• W1581248598 countsByYear W15812485982020 @default.
• W1581248598 countsByYear W15812485982021 @default.
• W1581248598 countsByYear W15812485982022 @default.
• W1581248598 countsByYear W15812485982023 @default.
• W1581248598 crossrefType "journal-article" @default.
• W1581248598 hasAuthorship W1581248598A5005087327 @default.
• W1581248598 hasAuthorship W1581248598A5029437943 @default.
• W1581248598 hasAuthorship W1581248598A5032205498 @default.
• W1581248598 hasAuthorship W1581248598A5032538286 @default.
• W1581248598 hasAuthorship W1581248598A5037474461 @default.
• W1581248598 hasAuthorship W1581248598A5050912249 @default.
• W1581248598 hasAuthorship W1581248598A5052708012 @default.
• W1581248598 hasAuthorship W1581248598A5087055576 @default.
• W1581248598 hasConcept C104317684 @default.
• W1581248598 hasConcept C118131993 @default.
• W1581248598 hasConcept C127561419 @default.
• W1581248598 hasConcept C139447449 @default.
• W1581248598 hasConcept C142724271 @default.
• W1581248598 hasConcept C158617107 @default.
• W1581248598 hasConcept C173396325 @default.
• W1581248598 hasConcept C18903297 @default.
• W1581248598 hasConcept C190283241 @default.
• W1581248598 hasConcept C2779965526 @default.
• W1581248598 hasConcept C2780559512 @default.
• W1581248598 hasConcept C2781080636 @default.
• W1581248598 hasConcept C2781244666 @default.
• W1581248598 hasConcept C2781331208 @default.
• W1581248598 hasConcept C502942594 @default.
• W1581248598 hasConcept C54458228 @default.
• W1581248598 hasConcept C55493867 @default.
• W1581248598 hasConcept C67705224 @default.
• W1581248598 hasConcept C71924100 @default.
• W1581248598 hasConcept C76419328 @default.
• W1581248598 hasConcept C86803240 @default.
• W1581248598 hasConcept C95444343 @default.
• W1581248598 hasConceptScore W1581248598C104317684 @default.
• W1581248598 hasConceptScore W1581248598C118131993 @default.
• W1581248598 hasConceptScore W1581248598C127561419 @default.
• W1581248598 hasConceptScore W1581248598C139447449 @default.
• W1581248598 hasConceptScore W1581248598C142724271 @default.
• W1581248598 hasConceptScore W1581248598C158617107 @default.
• W1581248598 hasConceptScore W1581248598C173396325 @default.
• W1581248598 hasConceptScore W1581248598C18903297 @default.
• W1581248598 hasConceptScore W1581248598C190283241 @default.
• W1581248598 hasConceptScore W1581248598C2779965526 @default.
• W1581248598 hasConceptScore W1581248598C2780559512 @default.
• W1581248598 hasConceptScore W1581248598C2781080636 @default.
• W1581248598 hasConceptScore W1581248598C2781244666 @default.
• W1581248598 hasConceptScore W1581248598C2781331208 @default.
• W1581248598 hasConceptScore W1581248598C502942594 @default.
• W1581248598 hasConceptScore W1581248598C54458228 @default.
• W1581248598 hasConceptScore W1581248598C55493867 @default.
• W1581248598 hasConceptScore W1581248598C67705224 @default.
• W1581248598 hasConceptScore W1581248598C71924100 @default.
• W1581248598 hasConceptScore W1581248598C76419328 @default.
• W1581248598 hasConceptScore W1581248598C86803240 @default.
• W1581248598 hasConceptScore W1581248598C95444343 @default.
• W1581248598 hasFunder F4320321001 @default.
• W1581248598 hasLocation W15812485981 @default.

• next