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• W1581362348 startingPage "8572" @default.
• W1581362348 abstract "A circadian clock is located in the retinal photoreceptors of the African clawed frog Xenopus laevis . These photoreceptor clocks are thought to govern a wide variety of output rhythms, including melatonin release and gene expression. Both light and dopamine phase shift the retinal clock in a phase-dependent manner. Two homologs of the Drosophila period gene have been cloned in Xenopus , and one of these ( xPer2 ) is acutely regulated by light. Light and dopamine induce xPer2 mRNA in a similar manner. In addition, the increase of xPer2 mRNA in response to light and dopamine is the same at all times of day tested. In contrast, xPer1 mRNA exhibits circadian oscillations but is relatively insensitive to phase-shifting treatments of light or dopamine. Our data suggest that xPer2 functions as the molecular link between the light/dark cycle and the circadian clock." @default.
• W1581362348 created "2016-06-24" @default.
• W1581362348 creator A5054064862 @default.
• W1581362348 creator A5066221707 @default.
• W1581362348 date "2000-12-01" @default.
• W1581362348 modified "2023-10-12" @default.
• W1581362348 title "Phase Shifting the Retinal Circadian Clock:<i>xPer2</i>mRNA Induction by Light and Dopamine" @default.
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• W1581362348 doi "https://doi.org/10.1523/jneurosci.20-23-08572.2000" @default.
• W1581362348 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6773079" @default.
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