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- W1581390083 abstract "Numerical aberrations (whole chromosomal aneuploidy) represent a significant proportion of chromosomal changes found in humans. These aberrations can occur as a consequence of chromosome segregation defects during cell division. Segregation errors arising during reductive cell division, or meiosis, are upon fertilisation and subsequent embryo development constitutively present in all cells, resulting in whole organismal aneuploidy. Missegregation in mitosis leads to a mosaic distribution of aneuploidy. Aneuploidy is associated with pathological states in most organisms. Numerical aberrations represent a significant cause of pregnancy loss as well as abnormalities found in live births. Moreover, numerical aberrations are frequently found in ageing tissues or in tumour cells. Although the association of aneuploidy and cancer is known for almost a century, the dispute is still ongoing whether this is a cause or a consequence of cell transformation. Recently, new evidence is emerging that numerical aberrations significantly alter the physiology of eukaryotic cells and might indeed directly contribute to tumorigenesis.Key Concepts: Numerical chromosomal aberrations result from errors in chromosome segregations.Trisomy, monosomy and polyploidy are among the major causes of spontaneous human abortions.Trisomies compatible with survival often result in multiple defects.Numerical chromosomal aberrations significantly alter physiology of eukaryotic cells.Numerical chromosomal aberrations are frequently found in cancer cells and can contribute to tumorigenesis.Keywords:numerical aberrations;aneuploidy;polyploidy;trisomy;tetraploidy;cancer" @default.
- W1581390083 created "2016-06-24" @default.
- W1581390083 creator A5044856730 @default.
- W1581390083 date "2011-01-17" @default.
- W1581390083 modified "2023-09-24" @default.
- W1581390083 title "Numerical Chromosomal Aberrations in Human Diseases" @default.
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- W1581390083 doi "https://doi.org/10.1002/9780470015902.a0001451.pub2" @default.
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