FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1581553688> ?p ?o ?g. }

• W1581553688 endingPage "237" @default.
• W1581553688 startingPage "227" @default.
• W1581553688 abstract "Millions of clotting tests each year require recalcification of blood treated with sodium citrate, a calcium chelator that prevents prothrombinase assembly. We validated a converging trifurcated microfluidic device to measure platelet and fibrin accumulation following on-chip recalcification of citrated whole blood. Recalcification was accomplished by sheathing the blood with Ca2+ buffer. Fluorescein rapidly diffused across the buffer-blood interface (achieving 62.5% of maximum centerline concentration within ~4 cm of flow), while albumin remained relatively unchanged in blood due to its lower diffusivity (<20% decrease). Since Ca2+ diffuses faster than fluorescein, full recalcification of whole blood was achieved within ~1 cm of flow prior to encountering a collagen/tissue surface. Platelet and fibrin were reduced by 87.3% and 99.0%, respectively, when the sheath buffer was Ca2+-free. A 30-min preincubation of citrated whole blood prior to on-chip recalcification increased platelet (159%) and fibrin (86.6%) deposition, compared to 5-min preincubation, likely due to factor XIIa generation in citrated blood. The P2Y1 inhibitor, MRS-2179, was delivered by diffusion into flowing blood and inhibited platelet deposition on collagen with a calculated IC50 of 0.155 μM. On-chip recalcification and drug dosing of citrated blood allows for assays of platelet function in a whole blood milieu under flow." @default.
• W1581553688 created "2016-06-24" @default.
• W1581553688 creator A5019405351 @default.
• W1581553688 creator A5065179734 @default.
• W1581553688 date "2014-01-01" @default.
• W1581553688 modified "2023-09-24" @default.
• W1581553688 title "Rapid on-chip recalcification and drug dosing of citrated whole blood using microfluidic buffer sheath flow" @default.
• W1581553688 cites W101550465 @default.
• W1581553688 cites W1487986660 @default.
• W1581553688 cites W1499842536 @default.
• W1581553688 cites W187459506 @default.
• W1581553688 cites W1978240589 @default.
• W1581553688 cites W1980877776 @default.
• W1581553688 cites W1982303101 @default.
• W1581553688 cites W1985622962 @default.
• W1581553688 cites W1986419282 @default.
• W1581553688 cites W1990718051 @default.
• W1581553688 cites W2008971450 @default.
• W1581553688 cites W2021732224 @default.
• W1581553688 cites W2034921547 @default.
• W1581553688 cites W2053676833 @default.
• W1581553688 cites W2058293803 @default.
• W1581553688 cites W2071156500 @default.
• W1581553688 cites W2083733554 @default.
• W1581553688 cites W2093411638 @default.
• W1581553688 cites W2101613467 @default.
• W1581553688 cites W2116855527 @default.
• W1581553688 cites W2119446923 @default.
• W1581553688 cites W2121221073 @default.
• W1581553688 cites W2138987190 @default.
• W1581553688 cites W2896903007 @default.
• W1581553688 cites W62415096 @default.
• W1581553688 doi "https://doi.org/10.3233/bir-140658" @default.
• W1581553688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24898333" @default.
• W1581553688 hasPublicationYear "2014" @default.
• W1581553688 type Work @default.
• W1581553688 sameAs 1581553688 @default.
• W1581553688 citedByCount "8" @default.
• W1581553688 countsByYear W15815536882015 @default.
• W1581553688 countsByYear W15815536882016 @default.
• W1581553688 countsByYear W15815536882017 @default.
• W1581553688 countsByYear W15815536882018 @default.
• W1581553688 countsByYear W15815536882020 @default.
• W1581553688 countsByYear W15815536882021 @default.
• W1581553688 crossrefType "journal-article" @default.
• W1581553688 hasAuthorship W1581553688A5019405351 @default.
• W1581553688 hasAuthorship W1581553688A5065179734 @default.
• W1581553688 hasConcept C126322002 @default.
• W1581553688 hasConcept C136229726 @default.
• W1581553688 hasConcept C141071460 @default.
• W1581553688 hasConcept C158846371 @default.
• W1581553688 hasConcept C1621761 @default.
• W1581553688 hasConcept C171250308 @default.
• W1581553688 hasConcept C185592680 @default.
• W1581553688 hasConcept C192562407 @default.
• W1581553688 hasConcept C203014093 @default.
• W1581553688 hasConcept C2776125364 @default.
• W1581553688 hasConcept C2988198817 @default.
• W1581553688 hasConcept C43617362 @default.
• W1581553688 hasConcept C54173615 @default.
• W1581553688 hasConcept C55493867 @default.
• W1581553688 hasConcept C71924100 @default.
• W1581553688 hasConcept C8673954 @default.
• W1581553688 hasConcept C89560881 @default.
• W1581553688 hasConceptScore W1581553688C126322002 @default.
• W1581553688 hasConceptScore W1581553688C136229726 @default.
• W1581553688 hasConceptScore W1581553688C141071460 @default.
• W1581553688 hasConceptScore W1581553688C158846371 @default.
• W1581553688 hasConceptScore W1581553688C1621761 @default.
• W1581553688 hasConceptScore W1581553688C171250308 @default.
• W1581553688 hasConceptScore W1581553688C185592680 @default.
• W1581553688 hasConceptScore W1581553688C192562407 @default.
• W1581553688 hasConceptScore W1581553688C203014093 @default.
• W1581553688 hasConceptScore W1581553688C2776125364 @default.
• W1581553688 hasConceptScore W1581553688C2988198817 @default.
• W1581553688 hasConceptScore W1581553688C43617362 @default.
• W1581553688 hasConceptScore W1581553688C54173615 @default.
• W1581553688 hasConceptScore W1581553688C55493867 @default.
• W1581553688 hasConceptScore W1581553688C71924100 @default.
• W1581553688 hasConceptScore W1581553688C8673954 @default.
• W1581553688 hasConceptScore W1581553688C89560881 @default.
• W1581553688 hasIssue "2-3" @default.
• W1581553688 hasLocation W15815536881 @default.
• W1581553688 hasLocation W15815536882 @default.
• W1581553688 hasOpenAccess W1581553688 @default.
• W1581553688 hasPrimaryLocation W15815536881 @default.
• W1581553688 hasRelatedWork W1726583457 @default.
• W1581553688 hasRelatedWork W1798271703 @default.
• W1581553688 hasRelatedWork W2015902705 @default.
• W1581553688 hasRelatedWork W2048878619 @default.
• W1581553688 hasRelatedWork W2462901255 @default.
• W1581553688 hasRelatedWork W2463468111 @default.
• W1581553688 hasRelatedWork W2465051201 @default.
• W1581553688 hasRelatedWork W2979622327 @default.
• W1581553688 hasRelatedWork W3004783112 @default.
• W1581553688 hasRelatedWork W4323826591 @default.
• W1581553688 hasVolume "51" @default.
• W1581553688 isParatext "false" @default.

• next