FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1581569396> ?p ?o ?g. }

• W1581569396 endingPage "1514" @default.
• W1581569396 startingPage "1499" @default.
• W1581569396 abstract "It is well known that the “free” form of glycans that are structurally related to asparagine (N)-linked glycans (“free N-glycans”) are found in a wide variety of organisms. The mechanisms responsible for the formation/degradation of high mannose-type free N-glycans have been extensively studied in mammalian cells. Recent evidence, however, also suggests that sialylated, complex-type free N-glycans are also present in the cytosol of various mammalian-derived cultured cells/tissues. We report herein on an investigation of the mechanism responsible for the degradation of such sialyl free N-glycans. The findings show that the amount of glycans is dramatically reduced upon the co-expression of cytosolic sialidase NEU2 with cytosolic β-glycosidase GBA3 in human stomach cancer-derived MKN45 cells. The physical interaction between NEU2 and GBA3 was confirmed by co-precipitation analyses as well as gel filtration assays. The NEU2 protein was found to be stabilized in the presence of GBA3 both in cellulo and in vitro. Our results thus indicate that cytosolic GBA3 is likely involved in the catabolism of cytosolic sialyl free N-glycans, possibly by stabilizing the activity of the NEU2 protein." @default.
• W1581569396 created "2016-06-24" @default.
• W1581569396 creator A5009512429 @default.
• W1581569396 creator A5012278873 @default.
• W1581569396 creator A5017194470 @default.
• W1581569396 creator A5054250942 @default.
• W1581569396 creator A5056686968 @default.
• W1581569396 creator A5065429379 @default.
• W1581569396 date "2015-07-16" @default.
• W1581569396 modified "2023-09-22" @default.
• W1581569396 title "Co-Expression of NEU2 and GBA3 Causes a Drastic Reduction in Cytosolic Sialyl Free N-glycans in Human MKN45 Stomach Cancer Cells—Evidence for the Physical Interaction of NEU2 and GBA3" @default.
• W1581569396 cites W1515107397 @default.
• W1581569396 cites W1571957427 @default.
• W1581569396 cites W1578795160 @default.
• W1581569396 cites W1584630693 @default.
• W1581569396 cites W1601276957 @default.
• W1581569396 cites W1674715246 @default.
• W1581569396 cites W1872184364 @default.
• W1581569396 cites W1935309887 @default.
• W1581569396 cites W1969846931 @default.
• W1581569396 cites W1974351333 @default.
• W1581569396 cites W1979563252 @default.
• W1581569396 cites W1980967211 @default.
• W1581569396 cites W1980992616 @default.
• W1581569396 cites W1993144174 @default.
• W1581569396 cites W1995701455 @default.
• W1581569396 cites W2000163527 @default.
• W1581569396 cites W2002582715 @default.
• W1581569396 cites W2007107152 @default.
• W1581569396 cites W2008905101 @default.
• W1581569396 cites W2010751343 @default.
• W1581569396 cites W2013286531 @default.
• W1581569396 cites W2019255055 @default.
• W1581569396 cites W2025259722 @default.
• W1581569396 cites W2025611972 @default.
• W1581569396 cites W2027547993 @default.
• W1581569396 cites W2043466478 @default.
• W1581569396 cites W2049137765 @default.
• W1581569396 cites W2054936230 @default.
• W1581569396 cites W2056071596 @default.
• W1581569396 cites W2067578257 @default.
• W1581569396 cites W2071018154 @default.
• W1581569396 cites W2095013880 @default.
• W1581569396 cites W2095210314 @default.
• W1581569396 cites W2104984801 @default.
• W1581569396 cites W2109315211 @default.
• W1581569396 cites W2119495183 @default.
• W1581569396 cites W2129232972 @default.
• W1581569396 cites W2149369491 @default.
• W1581569396 cites W2156386969 @default.
• W1581569396 cites W2168057450 @default.
• W1581569396 doi "https://doi.org/10.3390/biom5031499" @default.
• W1581569396 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4598761" @default.
• W1581569396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26193330" @default.
• W1581569396 hasPublicationYear "2015" @default.
• W1581569396 type Work @default.
• W1581569396 sameAs 1581569396 @default.
• W1581569396 citedByCount "11" @default.
• W1581569396 countsByYear W15815693962016 @default.
• W1581569396 countsByYear W15815693962017 @default.
• W1581569396 countsByYear W15815693962019 @default.
• W1581569396 countsByYear W15815693962020 @default.
• W1581569396 countsByYear W15815693962021 @default.
• W1581569396 countsByYear W15815693962022 @default.
• W1581569396 crossrefType "journal-article" @default.
• W1581569396 hasAuthorship W1581569396A5009512429 @default.
• W1581569396 hasAuthorship W1581569396A5012278873 @default.
• W1581569396 hasAuthorship W1581569396A5017194470 @default.
• W1581569396 hasAuthorship W1581569396A5054250942 @default.
• W1581569396 hasAuthorship W1581569396A5056686968 @default.
• W1581569396 hasAuthorship W1581569396A5065429379 @default.
• W1581569396 hasBestOaLocation W15815693961 @default.
• W1581569396 hasConcept C108625454 @default.
• W1581569396 hasConcept C134164806 @default.
• W1581569396 hasConcept C181199279 @default.
• W1581569396 hasConcept C185592680 @default.
• W1581569396 hasConcept C206212055 @default.
• W1581569396 hasConcept C2775928797 @default.
• W1581569396 hasConcept C55493867 @default.
• W1581569396 hasConcept C73695083 @default.
• W1581569396 hasConcept C86803240 @default.
• W1581569396 hasConcept C98539663 @default.
• W1581569396 hasConceptScore W1581569396C108625454 @default.
• W1581569396 hasConceptScore W1581569396C134164806 @default.
• W1581569396 hasConceptScore W1581569396C181199279 @default.
• W1581569396 hasConceptScore W1581569396C185592680 @default.
• W1581569396 hasConceptScore W1581569396C206212055 @default.
• W1581569396 hasConceptScore W1581569396C2775928797 @default.
• W1581569396 hasConceptScore W1581569396C55493867 @default.
• W1581569396 hasConceptScore W1581569396C73695083 @default.
• W1581569396 hasConceptScore W1581569396C86803240 @default.
• W1581569396 hasConceptScore W1581569396C98539663 @default.
• W1581569396 hasIssue "3" @default.
• W1581569396 hasLocation W15815693961 @default.
• W1581569396 hasLocation W15815693962 @default.
• W1581569396 hasLocation W15815693963 @default.
• W1581569396 hasLocation W15815693964 @default.
• W1581569396 hasLocation W15815693965 @default.

• next