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- W1581639643 abstract "Background This review is an update of a previously published review in the Cochrane Database of Systematic Reviews, 2005, Issue 4 (and last updated in the Cochrane Database of Systematic Reviews, 2013 issue 8), on local anaesthetic blockade (LASB) of the sympathetic chain to treat people with complex regional pain syndrome (CRPS). Objectives To assess the efficacy of LASB for the treatment of pain in CRPS and to evaluate the incidence of adverse effects of the procedure. Search methods For this update we searched the Cochrane Central Register of Controlled Trials (CENTRAL) (2015, Issue 9), MEDLINE (Ovid), EMBASE (Ovid), LILACS (Birme), conference abstracts of the World Congresses of the International Association for the Study of Pain, and various clinical trial registers up to September 2015. We also searched bibliographies from retrieved articles for additional studies. Selection criteria We considered randomised controlled trials (RCTs) that evaluated the effect of sympathetic blockade with local anaesthetics in children or adults with CRPS compared to placebo, no treatment, or alternative treatments. Data collection and analysis We used standard methodological procedures expected by Cochrane. The outcomes of interest were reduction in pain intensity, the proportion who achieved moderate or substantial pain relief, the duration of pain relief, and the presence of adverse effects in each treatment arm. We assessed the evidence using GRADE (Grading of Recommendations Assessment, Development and Evaluation) and created a 'Summary of findings' table. Main results We included an additional four studies (N = 154) in this update. For this update, we excluded studies that did not follow up patients for more than 48 hours. As a result, we excluded four studies from the previous review in this update. Overall we included 12 studies (N = 461), all of which we judged to be at high or unclear risk of bias. Overall, the quality of evidence was low to very low, downgraded due to limitations, inconsistency, imprecision, indirectness, or a combination of these. Two small studies compared LASB to placebo/sham (N = 32). They did not demonstrate significant short‐term benefit for LASB for pain intensity (moderate quality evidence). One small study (N = 36) at high risk of bias compared thoracic sympathetic block with corticosteroid and local anaesthetic versus injection of the same agents into the subcutaneous space, reporting statistically significant and clinically important differences in pain intensity at one‐year follow‐up but not at short term follow‐up (very low quality evidence). Of two studies that investigated LASB as an addition to rehabilitation treatment, the only study that reported pain outcomes demonstrated no additional benefit from LASB (very low quality evidence). Eight small randomised studies compared sympathetic blockade to various other active interventions. Most studies found no difference in pain outcomes between sympathetic block versus other active treatments (low to very low quality evidence). One small study compared ultrasound‐guided LASB with non‐guided LASB and found no clinically important difference in pain outcomes (very low quality evidence). Six studies reported adverse events, all with minor effects reported. Authors' conclusions This update's results are similar to the previous versions of this systematic review, and the main conclusions are unchanged. There remains a scarcity of published evidence and a lack of high quality evidence to support or refute the use of local anaesthetic sympathetic blockade for CRPS. From the existing evidence, it is not possible to draw firm conclusions regarding the efficacy or safety of this intervention, but the limited data available do not suggest that LASB is effective for reducing pain in CRPS." @default.
- W1581639643 created "2016-06-24" @default.
- W1581639643 creator A5026675498 @default.
- W1581639643 creator A5031592308 @default.
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- W1581639643 creator A5052957485 @default.
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- W1581639643 date "2016-07-28" @default.
- W1581639643 modified "2023-10-18" @default.
- W1581639643 title "Local anaesthetic sympathetic blockade for complex regional pain syndrome" @default.
- W1581639643 cites W1525335330 @default.
- W1581639643 cites W1578183859 @default.
- W1581639643 cites W1592220606 @default.
- W1581639643 cites W1756373912 @default.
- W1581639643 cites W1902297811 @default.
- W1581639643 cites W1965336550 @default.
- W1581639643 cites W1966892791 @default.
- W1581639643 cites W1967485326 @default.
- W1581639643 cites W1977002299 @default.
- W1581639643 cites W1977521225 @default.
- W1581639643 cites W1979445662 @default.
- W1581639643 cites W1981680557 @default.
- W1581639643 cites W1981912417 @default.
- W1581639643 cites W1986025099 @default.
- W1581639643 cites W1987637078 @default.
- W1581639643 cites W1987844466 @default.
- W1581639643 cites W1989091815 @default.
- W1581639643 cites W1993578629 @default.
- W1581639643 cites W2005310230 @default.
- W1581639643 cites W2012701523 @default.
- W1581639643 cites W2013584639 @default.
- W1581639643 cites W2013853273 @default.
- W1581639643 cites W2017878270 @default.
- W1581639643 cites W2018401949 @default.
- W1581639643 cites W2018982768 @default.
- W1581639643 cites W2020179518 @default.
- W1581639643 cites W2020243063 @default.
- W1581639643 cites W2033603665 @default.
- W1581639643 cites W2035335527 @default.
- W1581639643 cites W2037368413 @default.
- W1581639643 cites W2045288785 @default.
- W1581639643 cites W2048577929 @default.
- W1581639643 cites W2050196051 @default.
- W1581639643 cites W2051278984 @default.
- W1581639643 cites W2056042456 @default.
- W1581639643 cites W2056285559 @default.
- W1581639643 cites W2056709491 @default.
- W1581639643 cites W2057478171 @default.
- W1581639643 cites W2058652462 @default.
- W1581639643 cites W2059469444 @default.
- W1581639643 cites W2061974517 @default.
- W1581639643 cites W2068486728 @default.
- W1581639643 cites W2074205925 @default.
- W1581639643 cites W2076293971 @default.
- W1581639643 cites W2078835961 @default.
- W1581639643 cites W2079166493 @default.
- W1581639643 cites W2079827951 @default.
- W1581639643 cites W2080049061 @default.
- W1581639643 cites W2090056166 @default.
- W1581639643 cites W2091136954 @default.
- W1581639643 cites W2098998592 @default.
- W1581639643 cites W2104675861 @default.
- W1581639643 cites W2105352739 @default.
- W1581639643 cites W2105939522 @default.
- W1581639643 cites W2108978334 @default.
- W1581639643 cites W2111691078 @default.
- W1581639643 cites W2117653197 @default.
- W1581639643 cites W2118519935 @default.
- W1581639643 cites W2121463325 @default.
- W1581639643 cites W2122073564 @default.
- W1581639643 cites W2125435699 @default.
- W1581639643 cites W2125523803 @default.
- W1581639643 cites W2126435446 @default.
- W1581639643 cites W2131386387 @default.
- W1581639643 cites W2131769989 @default.
- W1581639643 cites W2135400982 @default.
- W1581639643 cites W2137232129 @default.
- W1581639643 cites W2139927756 @default.
- W1581639643 cites W2142775840 @default.
- W1581639643 cites W2143077460 @default.
- W1581639643 cites W2143082117 @default.
- W1581639643 cites W2143241524 @default.
- W1581639643 cites W2147076238 @default.
- W1581639643 cites W2147599802 @default.
- W1581639643 cites W2151225878 @default.
- W1581639643 cites W2159340522 @default.
- W1581639643 cites W2160795579 @default.
- W1581639643 cites W2161344815 @default.
- W1581639643 cites W2163345643 @default.
- W1581639643 cites W2168010323 @default.
- W1581639643 cites W2168189344 @default.
- W1581639643 cites W2170289289 @default.
- W1581639643 cites W4214559180 @default.
- W1581639643 cites W4231047922 @default.
- W1581639643 cites W4243871621 @default.
- W1581639643 cites W4244810506 @default.
- W1581639643 cites W4297952586 @default.
- W1581639643 cites W4323874076 @default.
- W1581639643 cites W83778090 @default.