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- W1581646219 abstract "The fluorescent dye 10-N-nonyl acridine orange (NAO), known as specifically associated with mitochondria, has been reported to have a cytotoxic effect when high doses were applied to cells. Presently, the biochemical basis of its toxicity was investigated on isolated rat liver mitochondria. At low concentrations, NAO strongly inhibited state 3 respiration and ATP synthesis. At high concentrations, electron transport, ATP hydrolysis, Pi-transport and adenine nucleotide activities were also decreased. All these inhibitions can be explained by probe-cardiolipin interactions which could induce the collapse of energy conversion and/or the modification of membrane fluidity." @default.
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- W1581646219 date "1990-01-29" @default.
- W1581646219 modified "2023-10-18" @default.
- W1581646219 title "Specific interaction of the new fluorescent dye 10-N-nonyl acridine orange with inner mitochondrial membrane" @default.
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- W1581646219 doi "https://doi.org/10.1016/0014-5793(90)80112-v" @default.
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