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• W1581646313 abstract "Publisher Summary This chapter presents a study that examines the influence of both ring halogenation (5-F or 6-F atom on the phenyl ring) and α-methylation on the aliphatic side chain of tryptamine on brain monoamine oxidase (MAO) activity. It also determines the induction of head-twitch response (HTR) by these compounds in mice. The chapter also compares four different tryptamine derivatives: 5- and 6-fluoro-α-methyltryptamine (5 -FMT, 6-FMT) and 5- and 6-fluorotryptamine (5-FT, 6-FT). The results show that, in addition to being selective MAO-A inhibitors, 5- and 6-FMT markedly induce HTR; the two non-methylated derivatives, 5-FT and 6-FT, did not induce this response. These latter two non-methylated derivatives are also relatively weak MAO-A-selective inhibitors. From this, it seems reasonable to suggest that perhaps the induction of this animal behavior may be because of selective, probably intraneuronal, MAO-A inhibition. In the rat brain, the bulk of 5-HT oxidation is carried out within 5-HT synaptosomes. This supports the hypothesis that HTR induced by the α-methylated amphetamine metabolite p-OHA, or by a 5-HT biosynthesis precursor, 1-5-HTP, is greatly potentiated after high MAO-A-selective inhibition, but not after MAO-B-selective inhibition." @default.
• W1581646313 created "2016-06-24" @default.
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• W1581646313 date "1995-01-01" @default.
• W1581646313 modified "2023-09-24" @default.
• W1581646313 title "Chapter 27 Activation of brain 5-HT neurons by two alpha-methylated tryptamine derivatives" @default.
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• W1581646313 doi "https://doi.org/10.1016/s0079-6123(08)61223-6" @default.
• W1581646313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8584663" @default.
• W1581646313 hasPublicationYear "1995" @default.
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