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• W1581676381 abstract "We have characterized certain resident guinea-pig peritoneal macrophage surface alterations following treatment with concanavalin A (ConA) and succinyl-ConA (S-ConA). Studies employing scanning electron microscopy (SEM) have demonstrated that ConA, a tetrameric lectin, decreases dramatically the number of macrophage surface folds and ruffles although S-ConA, a dimeric derivative, is apparently not active. However, incubation of S-ConA-treated cells with rabbit anti-ConA (anti-ConA) restored this effect. The decrease in surface folds could not be observed in the presence of α-methyl-d-mannoside (αMM), a hapten sugar of ConA. We have performed several receptor-labeling transmission electron microscopy (TEM) studies employing ferritin-conjugated ConA (FT-ConA) and cationized ferritin (CF). These experiments indicate that the ConA receptor-FT-ConA complexes form (1) clusters on the plasmalemma and (2) adsorptive pinocytic vesicles lined with the ferritin label. At the same time scale, we have observed a redistribution of macrophage surface anionic sites following treatment with ConA or S-ConA plus anti-ConA but not S-ConA alone. The redistribution of anionic sites is abolished in the presence of αMM. The specificity of the CF label was checked by pre-incubating cells with poly-l-lysine (PLL) or neuraminidase and by employing normal ferritin. These studies provide evidence which support the concept of a directed movement of surface charges during adsorptive pinocytosis. We discuss the possible relevance of this concept with regard to regional alterations of pH at the plasmalemma and the contribution of these anions to the trans-pinosomal pH gradient through the Donnan potential." @default.
• W1581676381 created "2016-06-24" @default.
• W1581676381 creator A5017823059 @default.
• W1581676381 date "1980-08-01" @default.
• W1581676381 modified "2023-10-14" @default.
• W1581676381 title "Response of the resident macrophage to concanavalin A" @default.
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• W1581676381 doi "https://doi.org/10.1016/0014-4827(80)90079-8" @default.
• W1581676381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7408999" @default.
• W1581676381 hasPublicationYear "1980" @default.
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