Matches in SemOpenAlex for { <https://semopenalex.org/work/W158167875> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W158167875 endingPage "4" @default.
- W158167875 startingPage "61" @default.
- W158167875 abstract "Increased responsiveness to psychomotor stimulants can be produced by either chronic stimulant administration or by chronic dopamine receptor blockade. This study examined the role of nitric oxide in the development of neuroleptic-induced supersensitivity. N omega-nitro-L-arginine methyl ester hydrochloride (L-NAME) administered during chronic intraperitoneal (i.p.) haloperidol treatment (0.2 mg/kg/d for 14 d) was used to inhibit nitric oxide synthesis. Locomotor activity following a cocaine(i.p.) challenge injection (10 mg/kg) administered at 3 and 10 d after cessation of haloperidol treatment demonstrated the development of supersensitivity. Haloperidol animals pretreated with L-NAME i.p. (30 mg/kg) showed significantly less cocaine-stimulated locomotor activity on both tests than saline-pretreated animals. This finding suggests that nitric oxide is involved in haloperidol-induced supersensitivity and that a common neural mechanism may underlie the development of supersensitivity and stimulant-induced sensitization. This study also suggests that treatment with a nitric oxide synthesis inhibitor may decrease the side effects accompanying long-term treatment with antipsychotic medications." @default.
- W158167875 created "2016-06-24" @default.
- W158167875 creator A5059795137 @default.
- W158167875 creator A5073445104 @default.
- W158167875 date "1997-01-01" @default.
- W158167875 modified "2023-09-23" @default.
- W158167875 title "Nitric oxide synthesis inhibition attenuates haloperidol-induced supersensitivity." @default.
- W158167875 cites W1964308449 @default.
- W158167875 cites W1971165967 @default.
- W158167875 cites W1972190053 @default.
- W158167875 cites W1978618811 @default.
- W158167875 cites W1993308253 @default.
- W158167875 cites W2004422747 @default.
- W158167875 cites W2015230796 @default.
- W158167875 cites W2075068003 @default.
- W158167875 cites W2106862702 @default.
- W158167875 cites W2151872428 @default.
- W158167875 cites W2342953526 @default.
- W158167875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1188818" @default.
- W158167875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9002394" @default.
- W158167875 hasPublicationYear "1997" @default.
- W158167875 type Work @default.
- W158167875 sameAs 158167875 @default.
- W158167875 citedByCount "7" @default.
- W158167875 countsByYear W1581678752012 @default.
- W158167875 countsByYear W1581678752014 @default.
- W158167875 crossrefType "journal-article" @default.
- W158167875 hasAuthorship W158167875A5059795137 @default.
- W158167875 hasAuthorship W158167875A5073445104 @default.
- W158167875 hasConcept C134018914 @default.
- W158167875 hasConcept C185592680 @default.
- W158167875 hasConcept C2780557958 @default.
- W158167875 hasConcept C2780948584 @default.
- W158167875 hasConcept C513476851 @default.
- W158167875 hasConcept C519581460 @default.
- W158167875 hasConcept C71924100 @default.
- W158167875 hasConcept C98274493 @default.
- W158167875 hasConceptScore W158167875C134018914 @default.
- W158167875 hasConceptScore W158167875C185592680 @default.
- W158167875 hasConceptScore W158167875C2780557958 @default.
- W158167875 hasConceptScore W158167875C2780948584 @default.
- W158167875 hasConceptScore W158167875C513476851 @default.
- W158167875 hasConceptScore W158167875C519581460 @default.
- W158167875 hasConceptScore W158167875C71924100 @default.
- W158167875 hasConceptScore W158167875C98274493 @default.
- W158167875 hasIssue "1" @default.
- W158167875 hasLocation W1581678751 @default.
- W158167875 hasOpenAccess W158167875 @default.
- W158167875 hasPrimaryLocation W1581678751 @default.
- W158167875 hasRelatedWork W158167875 @default.
- W158167875 hasRelatedWork W1979343210 @default.
- W158167875 hasRelatedWork W1993123849 @default.
- W158167875 hasRelatedWork W2007771139 @default.
- W158167875 hasRelatedWork W2007928239 @default.
- W158167875 hasRelatedWork W2130402210 @default.
- W158167875 hasRelatedWork W2329658190 @default.
- W158167875 hasRelatedWork W2425801529 @default.
- W158167875 hasRelatedWork W2899084033 @default.
- W158167875 hasRelatedWork W3144050884 @default.
- W158167875 hasVolume "22" @default.
- W158167875 isParatext "false" @default.
- W158167875 isRetracted "false" @default.
- W158167875 magId "158167875" @default.
- W158167875 workType "article" @default.