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- W1581680 abstract "Among all the powder agglomeration processes, high shear wet granulation is one of the most commonly used techniques. It consists of the agglomeration of different powders through the addition of a granulating fluid and a vigorous mixing. Industries often turn to high shear granulation mainly to avoid segregation of critical components in a powder mixture, improve flowability and compactibility. Despite the great importance of this technique in many industrial activities, it is not totally clear how changes in the initial powder mixture or in process variables can affect the final product properties. Moreover, scale-up of high shear granulators is still difficult to perform.The present research mainly focuses on the high shear wet granulation of pharmaceutical powders. Particularly, this research aims at closing the gap in understanding the role of primary particle properties (e.g. composition, primary particle size distribution) and process parameters (e.g. mixing speed, liquid flow rate and amount) on the final granule characteristics. Scale-up effects on the powder flow patterns were investigated as well." @default.
- W1581680 created "2016-06-24" @default.
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- W1581680 date "2011-01-20" @default.
- W1581680 modified "2023-09-26" @default.
- W1581680 title "High shear wet granulation: process understanding and scale up" @default.
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