Matches in SemOpenAlex for { <https://semopenalex.org/work/W1581696391> ?p ?o ?g. }
- W1581696391 endingPage "229" @default.
- W1581696391 startingPage "220" @default.
- W1581696391 abstract "J. Neurochem. (2012) 120, 220–229. CYP46A1 is a neuron-specific cytochrome P450 that plays a pivotal role in maintaining cholesterol homeostasis in the CNS. However, the molecular mechanisms underlying human CYP46A1 expression are still poorly understood, partly because of the lack of a cellular model that expresses high levels of CYP46A1. Our previous studies demonstrated that specificity protein (Sp) transcription factors control CYP46A1 expression, and are probably responsible for cell-type specificity. Herein, we have differentiated Ntera2/cloneD1 cells into post-mitotic neurons and identified for the first time a human cell model that expresses high levels of CYP46A1 mRNA. Our results show a decrease in Sp1 protein levels, concomitant with the increase in CYP46A1 mRNA levels. This decrease was correlated with changes in the ratio of Sp proteins associated to the CYP46A1 proximal promoter. To examine if the increase in (Sp3 + Sp4)/Sp1 ratio was observed in other Sp-regulated promoters, we have selected four genes - reelin, glutamate receptor subunit zeta-1, glutamate receptor subunit epsilon-1 and μ-opioid receptor - known to be expressed in the human brain and analyzed the Sp proteins binding pattern to the promoter of these genes, in undifferentiated and differentiated Ntera2/cloneD1. Our data indicate that the dissociation of Sp1 from promoter regions is a common feature amongst Sp-regulated genes that are up-regulated after neuronal differentiation." @default.
- W1581696391 created "2016-06-24" @default.
- W1581696391 creator A5012175198 @default.
- W1581696391 creator A5015633310 @default.
- W1581696391 creator A5017275901 @default.
- W1581696391 creator A5041222469 @default.
- W1581696391 creator A5042233533 @default.
- W1581696391 creator A5067129053 @default.
- W1581696391 date "2011-11-28" @default.
- W1581696391 modified "2023-09-25" @default.
- W1581696391 title "Neuronal differentiation alters the ratio of Sp transcription factors recruited to the CYP46A1 promoter" @default.
- W1581696391 cites W1495782770 @default.
- W1581696391 cites W1550888393 @default.
- W1581696391 cites W1576601453 @default.
- W1581696391 cites W1591789321 @default.
- W1581696391 cites W1776914999 @default.
- W1581696391 cites W1812789581 @default.
- W1581696391 cites W1964165050 @default.
- W1581696391 cites W1966599992 @default.
- W1581696391 cites W1969712702 @default.
- W1581696391 cites W1970393142 @default.
- W1581696391 cites W1974652786 @default.
- W1581696391 cites W1977565897 @default.
- W1581696391 cites W1980323102 @default.
- W1581696391 cites W1987510752 @default.
- W1581696391 cites W1988012766 @default.
- W1581696391 cites W1989233727 @default.
- W1581696391 cites W1996261992 @default.
- W1581696391 cites W2006665051 @default.
- W1581696391 cites W2008698762 @default.
- W1581696391 cites W2018054938 @default.
- W1581696391 cites W2022460223 @default.
- W1581696391 cites W2025723633 @default.
- W1581696391 cites W2026114009 @default.
- W1581696391 cites W2027469999 @default.
- W1581696391 cites W2030918644 @default.
- W1581696391 cites W2033232797 @default.
- W1581696391 cites W2037852973 @default.
- W1581696391 cites W2043638322 @default.
- W1581696391 cites W2064111729 @default.
- W1581696391 cites W2065521581 @default.
- W1581696391 cites W2069589160 @default.
- W1581696391 cites W2073539043 @default.
- W1581696391 cites W2073585306 @default.
- W1581696391 cites W2080741391 @default.
- W1581696391 cites W2081722421 @default.
- W1581696391 cites W2089352389 @default.
- W1581696391 cites W2091983239 @default.
- W1581696391 cites W2095605218 @default.
- W1581696391 cites W2096654038 @default.
- W1581696391 cites W2103079024 @default.
- W1581696391 cites W2105423509 @default.
- W1581696391 cites W2106169455 @default.
- W1581696391 cites W2110710419 @default.
- W1581696391 cites W2113210499 @default.
- W1581696391 cites W2117842413 @default.
- W1581696391 cites W2118827241 @default.
- W1581696391 cites W2126627519 @default.
- W1581696391 cites W2131472300 @default.
- W1581696391 cites W2143827549 @default.
- W1581696391 cites W2150563642 @default.
- W1581696391 cites W2152697044 @default.
- W1581696391 cites W2155518349 @default.
- W1581696391 cites W2161245725 @default.
- W1581696391 cites W4230009228 @default.
- W1581696391 doi "https://doi.org/10.1111/j.1471-4159.2011.07577.x" @default.
- W1581696391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22060190" @default.
- W1581696391 hasPublicationYear "2011" @default.
- W1581696391 type Work @default.
- W1581696391 sameAs 1581696391 @default.
- W1581696391 citedByCount "16" @default.
- W1581696391 countsByYear W15816963912012 @default.
- W1581696391 countsByYear W15816963912013 @default.
- W1581696391 countsByYear W15816963912014 @default.
- W1581696391 countsByYear W15816963912015 @default.
- W1581696391 countsByYear W15816963912016 @default.
- W1581696391 countsByYear W15816963912019 @default.
- W1581696391 countsByYear W15816963912020 @default.
- W1581696391 countsByYear W15816963912021 @default.
- W1581696391 countsByYear W15816963912022 @default.
- W1581696391 crossrefType "journal-article" @default.
- W1581696391 hasAuthorship W1581696391A5012175198 @default.
- W1581696391 hasAuthorship W1581696391A5015633310 @default.
- W1581696391 hasAuthorship W1581696391A5017275901 @default.
- W1581696391 hasAuthorship W1581696391A5041222469 @default.
- W1581696391 hasAuthorship W1581696391A5042233533 @default.
- W1581696391 hasAuthorship W1581696391A5067129053 @default.
- W1581696391 hasBestOaLocation W15816963911 @default.
- W1581696391 hasConcept C101762097 @default.
- W1581696391 hasConcept C104292427 @default.
- W1581696391 hasConcept C104317684 @default.
- W1581696391 hasConcept C150194340 @default.
- W1581696391 hasConcept C153911025 @default.
- W1581696391 hasConcept C170493617 @default.
- W1581696391 hasConcept C55493867 @default.
- W1581696391 hasConcept C57467964 @default.
- W1581696391 hasConcept C61174792 @default.
- W1581696391 hasConcept C86339819 @default.