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- W1581866730 abstract "Doses of amphetamine were selected from the polyphasic mortality response curves for interaction studies with drugs representative of various pharmacologic groups that could be expected to interact with amphetamine. The results of these studies suggest that the interaction of a test drug with amphetamine is more fully described by employing several dosages of amphetamine in both the grouped and isolated situation rather than a single grouped and a single isolated dose. A difference in the amphetamine-drug interaction was found to exist not only in the grouped vs. the isolated situation but also between different dosages of amphetamine in the same situation. The indices employed for studying the interaction effects were gross behavior and the cumulative and total lethality counts. The results also indicate that one cannot extrapolate from the activity of a given pharmacologic agent against amphetamine lethality to other members of the same class." @default.
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- W1581866730 date "1966-11-01" @default.
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- W1581866730 title "Reconsideration of the central nervous system pharmacology of amphetamine" @default.
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- W1581866730 doi "https://doi.org/10.1016/0041-008x(66)90015-9" @default.
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