FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1581940649> ?p ?o ?g. }

• W1581940649 endingPage "45" @default.
• W1581940649 startingPage "1135" @default.
• W1581940649 abstract "The authors have obtained evidence that destruction of the retinal pigment epithelium (RPE) causes choriocapillaris (CC) atrophy. The observations led us to hypothesize that the RPE modulates CC structure and function. Rabbits received injections of sodium iodate, which selectively destroyed the RPE. The authors killed the rabbits at various times after iodate and examined the RPE and CC by fluorescein angiography, fundus photography, and light and electron microscopy. Fluorescein angiography and fundus photography revealed a pattern of retinopathy similar to that described by other investigators, eg, blood-retinal barrier breakdown and the patchy nature of the RPE/CC degeneration. One week after injection of iodate, the RPE transformed into a mixture of flattened, depigmented cells and plump, highly pigmented ones lying along Bruch's membrane. The CC appeared normal by light microscopy, but electron microscopy revealed changes indicating CC atrophy: degenerating endothelial cells (EC), EC that appeared normal but had reduced numbers of fenestrae, and pericapillary basal laminae that looped away from the endothelium, as if the latter had shrunk. One month after iodate, patches of Bruch's membrane were devoid of RPE, which was replaced by scar tissue. The CC was markedly atrophic over these patches, having reduced numbers of profiles and smaller lumina in those which remained. The CC appeared normal over areas where RPE remained. Eleven weeks after iodate, the light microscopic picture parallelled that seen 1 month after injection, but the patchy RPE degeneration was more extensive. By electron microscopy, the CC profiles over areas devoid of RPE showed severe atrophy. Degenerating EC were more numerous. EC adjacent to areas of RPE loss had few or no fenestrae. Here, capillaries were encased in dense, collagenous, connective tissue, unlike the CC of normal rabbits. These changes were not seen where the RPE still covered Bruch's membrane. These observations suggest that RPE modulates CC structure and function. The authors propose that a diffusible vascular modulating factor produced by RPE cells does this." @default.
• W1581940649 created "2016-06-24" @default.
• W1581940649 creator A5034980440 @default.
• W1581940649 creator A5079465902 @default.
• W1581940649 creator A5090041811 @default.
• W1581940649 date "1984-10-01" @default.
• W1581940649 modified "2023-10-01" @default.
• W1581940649 title "RPE destruction causes choriocapillary atrophy." @default.
• W1581940649 cites W181352239 @default.
• W1581940649 cites W19022953 @default.
• W1581940649 cites W1972657414 @default.
• W1581940649 cites W1972830950 @default.
• W1581940649 cites W1975619561 @default.
• W1581940649 cites W1979756211 @default.
• W1581940649 cites W2001096277 @default.
• W1581940649 cites W2059035015 @default.
• W1581940649 cites W2061532799 @default.
• W1581940649 cites W2075115097 @default.
• W1581940649 cites W2102604445 @default.
• W1581940649 cites W42392741 @default.
• W1581940649 cites W4744538 @default.
• W1581940649 cites W52269856 @default.
• W1581940649 cites W56769723 @default.
• W1581940649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6480292" @default.
• W1581940649 hasPublicationYear "1984" @default.
• W1581940649 type Work @default.
• W1581940649 sameAs 1581940649 @default.
• W1581940649 citedByCount "181" @default.
• W1581940649 countsByYear W15819406492012 @default.
• W1581940649 countsByYear W15819406492013 @default.
• W1581940649 countsByYear W15819406492014 @default.
• W1581940649 countsByYear W15819406492015 @default.
• W1581940649 countsByYear W15819406492016 @default.
• W1581940649 countsByYear W15819406492017 @default.
• W1581940649 countsByYear W15819406492018 @default.
• W1581940649 countsByYear W15819406492019 @default.
• W1581940649 countsByYear W15819406492020 @default.
• W1581940649 countsByYear W15819406492021 @default.
• W1581940649 countsByYear W15819406492022 @default.
• W1581940649 countsByYear W15819406492023 @default.
• W1581940649 crossrefType "journal-article" @default.
• W1581940649 hasAuthorship W1581940649A5034980440 @default.
• W1581940649 hasAuthorship W1581940649A5079465902 @default.
• W1581940649 hasAuthorship W1581940649A5090041811 @default.
• W1581940649 hasConcept C105702510 @default.
• W1581940649 hasConcept C118487528 @default.
• W1581940649 hasConcept C120665830 @default.
• W1581940649 hasConcept C121332964 @default.
• W1581940649 hasConcept C126322002 @default.
• W1581940649 hasConcept C142724271 @default.
• W1581940649 hasConcept C169760540 @default.
• W1581940649 hasConcept C185592680 @default.
• W1581940649 hasConcept C2776391266 @default.
• W1581940649 hasConcept C2776403814 @default.
• W1581940649 hasConcept C2776474195 @default.
• W1581940649 hasConcept C2776582655 @default.
• W1581940649 hasConcept C2776992346 @default.
• W1581940649 hasConcept C2777093970 @default.
• W1581940649 hasConcept C2778024200 @default.
• W1581940649 hasConcept C2779333224 @default.
• W1581940649 hasConcept C2780248432 @default.
• W1581940649 hasConcept C2780827179 @default.
• W1581940649 hasConcept C2781172350 @default.
• W1581940649 hasConcept C71924100 @default.
• W1581940649 hasConcept C86803240 @default.
• W1581940649 hasConcept C87555872 @default.
• W1581940649 hasConcept C93877712 @default.
• W1581940649 hasConceptScore W1581940649C105702510 @default.
• W1581940649 hasConceptScore W1581940649C118487528 @default.
• W1581940649 hasConceptScore W1581940649C120665830 @default.
• W1581940649 hasConceptScore W1581940649C121332964 @default.
• W1581940649 hasConceptScore W1581940649C126322002 @default.
• W1581940649 hasConceptScore W1581940649C142724271 @default.
• W1581940649 hasConceptScore W1581940649C169760540 @default.
• W1581940649 hasConceptScore W1581940649C185592680 @default.
• W1581940649 hasConceptScore W1581940649C2776391266 @default.
• W1581940649 hasConceptScore W1581940649C2776403814 @default.
• W1581940649 hasConceptScore W1581940649C2776474195 @default.
• W1581940649 hasConceptScore W1581940649C2776582655 @default.
• W1581940649 hasConceptScore W1581940649C2776992346 @default.
• W1581940649 hasConceptScore W1581940649C2777093970 @default.
• W1581940649 hasConceptScore W1581940649C2778024200 @default.
• W1581940649 hasConceptScore W1581940649C2779333224 @default.
• W1581940649 hasConceptScore W1581940649C2780248432 @default.
• W1581940649 hasConceptScore W1581940649C2780827179 @default.
• W1581940649 hasConceptScore W1581940649C2781172350 @default.
• W1581940649 hasConceptScore W1581940649C71924100 @default.
• W1581940649 hasConceptScore W1581940649C86803240 @default.
• W1581940649 hasConceptScore W1581940649C87555872 @default.
• W1581940649 hasConceptScore W1581940649C93877712 @default.
• W1581940649 hasIssue "10" @default.
• W1581940649 hasLocation W15819406491 @default.
• W1581940649 hasOpenAccess W1581940649 @default.
• W1581940649 hasPrimaryLocation W15819406491 @default.
• W1581940649 hasRelatedWork W1581940649 @default.
• W1581940649 hasRelatedWork W1968289616 @default.
• W1581940649 hasRelatedWork W2012930159 @default.
• W1581940649 hasRelatedWork W2164368448 @default.

• next