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• W1582018632 abstract "Interleukin (IL)‐6 is a pleiotropic cytokine that plays a key role in a wide variety of diseases. Based on a number of adjuvant‐induced experimental models, IL‐6 is critical to the development of autoimmune diseases including experimental autoimmune encephalomyelitis, adjuvant‐induced arthritis, and experimental autoimmune myocarditis. However, whether it plays a pathogenic role in viral‐induced autoimmune myocarditis has been less well defined. While experimental models of myocarditis have clearly linked IL‐6 to the generation of pathogenic autoreactive T cells, IL‐6 has exhibited a protective role in autoimmune disease development in viral‐induced disease models. As pathogen infection has been linked to the majority of myocarditis patients, treatments aimed at decreasing IL‐6 levels in the hopes of limiting the autoimmune response run the risk of increasing disease severity." @default.
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• W1582018632 date "2009-09-01" @default.
• W1582018632 modified "2023-09-27" @default.
• W1582018632 title "IL-6 during Viral-induced Chronic Autoimmune Myocarditis" @default.
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• W1582018632 doi "https://doi.org/10.1111/j.1749-6632.2009.04850.x" @default.
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