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- W1582068982 abstract "This chapter discusses examples of how nuclear magnetic resonance (NMR) can be used to investigate cerebral metabolism and monitor both the progression of disease and treatment. The basis for the NMR phenomenon arises from an intrinsic property of nuclei having odd numbers of protons or neutrons, and unpaired nuclear spins. Such nuclei possess a net spin angular momentum. The proportion of spins aligned (lower energy) or opposed (higher energy) with the field can be described statistically and is given by the Boltzman distribution. Detection of an NMR signal involves a perturbation of the magnetization from equilibrium. The tiny oscillating magnetic field generated by the sample can be detected with a suitable antenna (loop of wire) oriented perpendicular to the direction of the static field. N-acetylaspartate (NAA) is highly concentrated in animal and human brain and is considered the most prominent metabolite resonance in the 1H NMR spectrum. The concentrations of the high energy phosphates, phosphocreatine (PCr), and adenosine triphosphate (ATP) are substantial in brain and are readily detected using 31P NMR. Cerebral hypoxia and ischemia leads to rapid depletion of high energy phosphates, elevation of Pi, and cellular acidosis in animals and in patients with stroke." @default.
- W1582068982 created "2016-06-24" @default.
- W1582068982 creator A5090099139 @default.
- W1582068982 date "1997-01-01" @default.
- W1582068982 modified "2023-09-27" @default.
- W1582068982 title "Chapter 8 alternatives to mass spectrometry for quantitating stable isotopes: Application of nuclear magnetic resonance in brain metabolic research" @default.
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