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- W1582076866 abstract "Abstract Elevated cytokine IL-13 in serum has been associated with several autoimmune diseases, including Sjögren’s Syndrome. However, whether IL-13 plays an early and causative role in disease development is not known and cannot be easily studied in humans. Our previous work has shown that levels of the IL-13 are elevated in Id3 knockout mice, which has been established as a model for primary Sjögren’s Syndrome. Here, we utilized an IL-13 reporter to determine the source of the elevated IL-13 levels observed in Id3 knockout mice and assess its contribution to SS symptoms. Our results indicate that T cells, primarily CD4+ αβ T cells and γδ T cells, in Id3 knockout mice produce IL-13 at an elevated frequency well before disease symptoms become apparent. We also show that T cells developing early in life are more predisposed to produce IL-13. Finally, analysis of Id3 and IL-13 double deficient mice demonstrated that IL-13 plays an essential role in the deterioration of gland function. Our study indicates that enhanced IL-13 production by T cells is capable of inducing exocrinopathy in animal models." @default.
- W1582076866 created "2016-06-24" @default.
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- W1582076866 date "2014-05-01" @default.
- W1582076866 modified "2023-09-23" @default.
- W1582076866 title "Aberrant production of IL-13 by T cells promotes exocrinopathy in Id3 knockout mice (BA14P.206)" @default.
- W1582076866 doi "https://doi.org/10.4049/jimmunol.192.supp.178.7" @default.
- W1582076866 hasPublicationYear "2014" @default.
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