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- W1582092181 abstract "Dharnidharka and colleagues raise an important point. Co-stimulation blockade using anti-CD154 and CTLA4-Ig, albeit remarkably effective in many models, has not proven universally successful in producing permanent engraftment in allograft models. Although the cited work of Larsen and Pearson4 showed universal survival of skin allografts for 50 days, after further observation, only 50% of the recipients in that study experienced permanent engraftment (C. Larsen, personal communication). In skin graft models, subtle differences in the precise source of the skin graft, the source of CTLA4-Ig and differences in the C3H/He substrains are potentially very important in determining outcome. In fact, Larsen and Pearson have just shown in another strain combination that asialo GM1+ CD8+ T cells are essential in co-stimulation blockade-resistant mouse skin allograft rejection7. Several other groups have noted that CD8+ T cells are responsible for co-stimulation blockade resistant rejection in intestinal8 and skin9 allograft models. And our own unpublished observations show that co-stimulation blockade is ineffective in blocking islet allograft rejection in a CD8+ T-cell receptor transgenic model. We know of several other groups that have noted CD8+ T-cell-dependent, co-stimulation blockade resistant allograft rejection. Recall that the expression of the co-stimulatory proteins differs from CD4+ to CD8+ T cells." @default.
- W1582092181 created "2016-06-24" @default.
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- W1582092181 date "2000-02-01" @default.
- W1582092181 modified "2023-10-18" @default.
- W1582092181 title "Reply to Failure of combined costimulatory blockade in animal transplant model" @default.
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- W1582092181 doi "https://doi.org/10.1038/72168" @default.
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