Matches in SemOpenAlex for { <https://semopenalex.org/work/W1582225853> ?p ?o ?g. }
- W1582225853 abstract "Virus-specific cell-mediated immunity (CMI) plays a role in the outcome of genital HPV infections. To cast further light on the question why most women clear their HPV infection while others develop high-grade cervical intraepithelial neoplasia (CIN), we analyzed HPV16 E2-, E6- and E7 -specific CMI in women who developed CIN during a 10-year follow-up of the Finnish Family HPV cohort.Overlapping 30-35 mer peptides covering the entire HPV16 E2-, E6- and E7 protein sequences were used for defining the lymphocyte proliferation capacity, cytokine production (IL-2, IL-5, IL-10, IL-17A, IFN-γ and TNF-α) and numbers of HPV16 -specific CD4+ CD25+ Foxp3+ regulatory T-cells in 10 women who developed CIN, and in 22 control women who tested constantly HPV-negative during the follow-up. HPV-specific CMI was related to the demographic data including sexual behavior, smoking and alcohol consumption.Women with CIN and their controls had similar T-cell mediated immunity against HPV16 E2, E6 and E7 peptide pools. However, nearly fourfold higher T-cell reactivity against common antigens was found in the CIN women than in the healthy donors (p = 0.001). HPV16 E6 stimulation resulted in higher IL-17A secretion in the controls than in the CIN women (p = 0.035). Smoking and use of alcohol affected the T-cell response to common antigens but not to HPV peptides (p = 0.032 and 0.045, respectively).While both the CIN women and controls exhibited an HPV16-specific CMI, IL-17A might be of importance in HPV induced pathology. The hyper-responsiveness of the CIN patients to common antigens needs further studies. Smoking and alcohol had no effect on HPV-specific CMI." @default.
- W1582225853 created "2016-06-24" @default.
- W1582225853 creator A5017337687 @default.
- W1582225853 creator A5026783889 @default.
- W1582225853 creator A5030107910 @default.
- W1582225853 creator A5039765613 @default.
- W1582225853 creator A5041281028 @default.
- W1582225853 creator A5050490207 @default.
- W1582225853 creator A5069267169 @default.
- W1582225853 date "2015-05-20" @default.
- W1582225853 modified "2023-10-15" @default.
- W1582225853 title "Cell mediated immunity against HPV16 E2, E6 and E7 peptides in women with incident CIN and in constantly HPV-negative women followed-up for 10-years" @default.
- W1582225853 cites W1694278644 @default.
- W1582225853 cites W1737749102 @default.
- W1582225853 cites W1764705709 @default.
- W1582225853 cites W1856837495 @default.
- W1582225853 cites W1929537823 @default.
- W1582225853 cites W1967768009 @default.
- W1582225853 cites W1978576085 @default.
- W1582225853 cites W1995877369 @default.
- W1582225853 cites W1997632425 @default.
- W1582225853 cites W1998382013 @default.
- W1582225853 cites W2014985358 @default.
- W1582225853 cites W2036641307 @default.
- W1582225853 cites W2037560450 @default.
- W1582225853 cites W2038070129 @default.
- W1582225853 cites W2047777179 @default.
- W1582225853 cites W2052816509 @default.
- W1582225853 cites W2053562190 @default.
- W1582225853 cites W2065514654 @default.
- W1582225853 cites W2066771684 @default.
- W1582225853 cites W2066860562 @default.
- W1582225853 cites W2071822782 @default.
- W1582225853 cites W2073209828 @default.
- W1582225853 cites W2076437162 @default.
- W1582225853 cites W2077204887 @default.
- W1582225853 cites W2078907345 @default.
- W1582225853 cites W2085317066 @default.
- W1582225853 cites W2089963048 @default.
- W1582225853 cites W2092933935 @default.
- W1582225853 cites W2096866753 @default.
- W1582225853 cites W2097305227 @default.
- W1582225853 cites W2098737758 @default.
- W1582225853 cites W2100745065 @default.
- W1582225853 cites W2104407221 @default.
- W1582225853 cites W2109460972 @default.
- W1582225853 cites W2110977426 @default.
- W1582225853 cites W2116187458 @default.
- W1582225853 cites W2118094114 @default.
- W1582225853 cites W2129057663 @default.
- W1582225853 cites W2130472599 @default.
- W1582225853 cites W2130619064 @default.
- W1582225853 cites W2132980040 @default.
- W1582225853 cites W2133532268 @default.
- W1582225853 cites W2143734820 @default.
- W1582225853 cites W2151699896 @default.
- W1582225853 cites W2157247388 @default.
- W1582225853 cites W2158146640 @default.
- W1582225853 cites W2187678497 @default.
- W1582225853 cites W272874896 @default.
- W1582225853 doi "https://doi.org/10.1186/s12967-015-0498-9" @default.
- W1582225853 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4448180" @default.
- W1582225853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25990808" @default.
- W1582225853 hasPublicationYear "2015" @default.
- W1582225853 type Work @default.
- W1582225853 sameAs 1582225853 @default.
- W1582225853 citedByCount "12" @default.
- W1582225853 countsByYear W15822258532017 @default.
- W1582225853 countsByYear W15822258532018 @default.
- W1582225853 countsByYear W15822258532019 @default.
- W1582225853 countsByYear W15822258532020 @default.
- W1582225853 countsByYear W15822258532021 @default.
- W1582225853 countsByYear W15822258532022 @default.
- W1582225853 crossrefType "journal-article" @default.
- W1582225853 hasAuthorship W1582225853A5017337687 @default.
- W1582225853 hasAuthorship W1582225853A5026783889 @default.
- W1582225853 hasAuthorship W1582225853A5030107910 @default.
- W1582225853 hasAuthorship W1582225853A5039765613 @default.
- W1582225853 hasAuthorship W1582225853A5041281028 @default.
- W1582225853 hasAuthorship W1582225853A5050490207 @default.
- W1582225853 hasAuthorship W1582225853A5069267169 @default.
- W1582225853 hasBestOaLocation W15822258531 @default.
- W1582225853 hasConcept C121608353 @default.
- W1582225853 hasConcept C126322002 @default.
- W1582225853 hasConcept C147483822 @default.
- W1582225853 hasConcept C203014093 @default.
- W1582225853 hasConcept C2776090121 @default.
- W1582225853 hasConcept C2777343196 @default.
- W1582225853 hasConcept C2778220009 @default.
- W1582225853 hasConcept C2779341262 @default.
- W1582225853 hasConcept C2779727006 @default.
- W1582225853 hasConcept C71924100 @default.
- W1582225853 hasConcept C79484868 @default.
- W1582225853 hasConcept C8891405 @default.
- W1582225853 hasConceptScore W1582225853C121608353 @default.
- W1582225853 hasConceptScore W1582225853C126322002 @default.
- W1582225853 hasConceptScore W1582225853C147483822 @default.
- W1582225853 hasConceptScore W1582225853C203014093 @default.
- W1582225853 hasConceptScore W1582225853C2776090121 @default.
- W1582225853 hasConceptScore W1582225853C2777343196 @default.