FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1582251046> ?p ?o ?g. }

• W1582251046 endingPage "15577" @default.
• W1582251046 startingPage "15568" @default.
• W1582251046 abstract "The role of the NH2-terminal propeptide of human apolipoprotein (apo) AI in intracellular transport and lipid-protein interactions was examined by transfecting a murine anterior pituitary cell line (AtT-20) with the human preproapo AI gene and a mutant gene lacking the 18-base pair segment of exon III encoding its hexapeptide prosegment. ProapoAI was not processed to the mature apolipoprotein either prior to or after export from these cells making this an attractive model system for directly assessing structure/activity relationships of its propeptide. ApoAI was sorted into a regulated pathway for protein export. The signal responsible for this trafficking pattern was not contained in the prosegment since both pro- and mature ApoAI exhibited a similar rate of secretion, a similar magnitude of stimulation of export by the secretagogue 8-bromo-cyclic AMP, and similar targeting to dense core granules. This sorting behavior, exhibited by a protein which is not normally targeted to dense core secretory granules in its cells of origin, raises questions about the domains and mechanisms involved in protein sorting into the regulated and constitutive pathways of AtT-20 cells. Density gradient ultracentrifugation, immunoaffinity chromatographic and electron microscopic analysis indicated that approximately 10% of proapoAI and approximately 10% apoAI appeared in AtT-20 culture media in the form of two discrete classes of nascent lipoproteins: a small 6-8 nm spherical particle and a larger discoidal particle. These particles had morphologies identical with those secreted by Hep G2 cells which normally synthesize apolipoproteins. Although these results do not resolve the issue of whether or not a fraction of apoAI can act as an acceptor of cellular lipid during its transport through the secretory pathway, the data do show that this functional capability for lipoprotein assembly is not obviously regulated by its prosegment." @default.
• W1582251046 created "2016-06-24" @default.
• W1582251046 creator A5063884903 @default.
• W1582251046 creator A5088289645 @default.
• W1582251046 creator A5090853098 @default.
• W1582251046 date "1988-10-01" @default.
• W1582251046 modified "2023-10-14" @default.
• W1582251046 title "Expression of human preproapo AI and pre(delta pro)apoAI in a murine pituitary cell line (AtT-20). A comparison of their intracellular compartmentalization and lipid affiliation." @default.
• W1582251046 cites W1479219594 @default.
• W1582251046 cites W1503509538 @default.
• W1582251046 cites W1510550897 @default.
• W1582251046 cites W1512441345 @default.
• W1582251046 cites W1522544439 @default.
• W1582251046 cites W1528298906 @default.
• W1582251046 cites W1534631025 @default.
• W1582251046 cites W1537090944 @default.
• W1582251046 cites W1538392871 @default.
• W1582251046 cites W1540687701 @default.
• W1582251046 cites W1544618298 @default.
• W1582251046 cites W1547690943 @default.
• W1582251046 cites W1561049387 @default.
• W1582251046 cites W1571225670 @default.
• W1582251046 cites W1573759787 @default.
• W1582251046 cites W1585878980 @default.
• W1582251046 cites W1602260890 @default.
• W1582251046 cites W1635128112 @default.
• W1582251046 cites W165264657 @default.
• W1582251046 cites W1681019703 @default.
• W1582251046 cites W1941420237 @default.
• W1582251046 cites W1966583531 @default.
• W1582251046 cites W1966686403 @default.
• W1582251046 cites W1971608670 @default.
• W1582251046 cites W1974540651 @default.
• W1582251046 cites W1976998656 @default.
• W1582251046 cites W1979345671 @default.
• W1582251046 cites W1982939568 @default.
• W1582251046 cites W1983384469 @default.
• W1582251046 cites W1985870242 @default.
• W1582251046 cites W1985946610 @default.
• W1582251046 cites W1989249306 @default.
• W1582251046 cites W1991088315 @default.
• W1582251046 cites W1991167274 @default.
• W1582251046 cites W1995699883 @default.
• W1582251046 cites W1996238942 @default.
• W1582251046 cites W1999455524 @default.
• W1582251046 cites W1999881321 @default.
• W1582251046 cites W2006943139 @default.
• W1582251046 cites W2010978275 @default.
• W1582251046 cites W2023314628 @default.
• W1582251046 cites W2037936859 @default.
• W1582251046 cites W2042096080 @default.
• W1582251046 cites W2043187554 @default.
• W1582251046 cites W2050290881 @default.
• W1582251046 cites W2052996817 @default.
• W1582251046 cites W2058252905 @default.
• W1582251046 cites W2062395148 @default.
• W1582251046 cites W2067453762 @default.
• W1582251046 cites W2069958139 @default.
• W1582251046 cites W2072585523 @default.
• W1582251046 cites W2077419364 @default.
• W1582251046 cites W2085864418 @default.
• W1582251046 cites W2087997768 @default.
• W1582251046 cites W2089123414 @default.
• W1582251046 cites W2094364456 @default.
• W1582251046 cites W2100837269 @default.
• W1582251046 cites W2101108802 @default.
• W1582251046 cites W2123065833 @default.
• W1582251046 cites W2127747731 @default.
• W1582251046 cites W2130280839 @default.
• W1582251046 cites W2134634622 @default.
• W1582251046 cites W2138270253 @default.
• W1582251046 cites W2138879032 @default.
• W1582251046 cites W2143536256 @default.
• W1582251046 cites W2147018338 @default.
• W1582251046 cites W2149882637 @default.
• W1582251046 cites W2159869711 @default.
• W1582251046 cites W2171688880 @default.
• W1582251046 cites W2183954926 @default.
• W1582251046 cites W2207570231 @default.
• W1582251046 cites W2312450488 @default.
• W1582251046 cites W2338060946 @default.
• W1582251046 cites W2338151611 @default.
• W1582251046 cites W2425661354 @default.
• W1582251046 cites W2470854422 @default.
• W1582251046 cites W2773214419 @default.
• W1582251046 cites W937723691 @default.
• W1582251046 doi "https://doi.org/10.1016/s0021-9258(19)37626-4" @default.
• W1582251046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3170598" @default.
• W1582251046 hasPublicationYear "1988" @default.
• W1582251046 type Work @default.
• W1582251046 sameAs 1582251046 @default.
• W1582251046 citedByCount "23" @default.
• W1582251046 crossrefType "journal-article" @default.
• W1582251046 hasAuthorship W1582251046A5063884903 @default.
• W1582251046 hasAuthorship W1582251046A5088289645 @default.
• W1582251046 hasAuthorship W1582251046A5090853098 @default.
• W1582251046 hasBestOaLocation W15822510461 @default.
• W1582251046 hasConcept C110455231 @default.

• next