Matches in SemOpenAlex for { <https://semopenalex.org/work/W1582344896> ?p ?o ?g. }
- W1582344896 endingPage "157" @default.
- W1582344896 startingPage "147" @default.
- W1582344896 abstract "African swine fever virus is a large DNA virus which can cause an acute haemorrhagic fever in pigs resulting in high mortality. No vaccine is available, limiting options for control. The virus encodes up to 165 genes and virus particles are multi-layered and contain more than 50 proteins. Pigs immunised with natural low virulence isolates or attenuated viruses produced by passage in tissue culture and by targeted gene deletions can be protected against challenge with virulent viruses. CD8+ cells are required for protection induced by attenuated strain OURT88/3. Passive transfer of antibodies from immune to naïve pigs can also induce protection. Knowledge of the genome sequences of attenuated and virulent strains and targeted gene deletions from virulent strains have identified a number of virus genes involved in virulence and immune evasion. This information can be used to produce rationally attenuated vaccine strains. Virus antigens that are targets for neutralising antibodies have been identified and immunisation with these recombinant proteins has been shown to induce partial protection. However knowledge of antigens which encode the dominant protective epitopes recognised by CD8+ T cells is lacking." @default.
- W1582344896 created "2016-06-24" @default.
- W1582344896 creator A5009664981 @default.
- W1582344896 creator A5019076649 @default.
- W1582344896 creator A5037216277 @default.
- W1582344896 creator A5039902769 @default.
- W1582344896 creator A5065356926 @default.
- W1582344896 creator A5068058811 @default.
- W1582344896 creator A5072812686 @default.
- W1582344896 date "2013-01-01" @default.
- W1582344896 modified "2023-10-18" @default.
- W1582344896 title "Prospects for Development of African Swine Fever Virus Vaccines" @default.
- W1582344896 cites W1857660355 @default.
- W1582344896 cites W1964460757 @default.
- W1582344896 cites W1973144694 @default.
- W1582344896 cites W1977502961 @default.
- W1582344896 cites W1978958747 @default.
- W1582344896 cites W1980563424 @default.
- W1582344896 cites W1990866328 @default.
- W1582344896 cites W2007881500 @default.
- W1582344896 cites W2013874066 @default.
- W1582344896 cites W2016158866 @default.
- W1582344896 cites W2017019498 @default.
- W1582344896 cites W2025300828 @default.
- W1582344896 cites W2030054290 @default.
- W1582344896 cites W2035391853 @default.
- W1582344896 cites W2035536024 @default.
- W1582344896 cites W2039622301 @default.
- W1582344896 cites W2041339670 @default.
- W1582344896 cites W2050126429 @default.
- W1582344896 cites W2061005003 @default.
- W1582344896 cites W2062096354 @default.
- W1582344896 cites W2063380914 @default.
- W1582344896 cites W2071675636 @default.
- W1582344896 cites W2080559106 @default.
- W1582344896 cites W2081388900 @default.
- W1582344896 cites W2084681388 @default.
- W1582344896 cites W2085907970 @default.
- W1582344896 cites W2086833170 @default.
- W1582344896 cites W2087601007 @default.
- W1582344896 cites W2091184098 @default.
- W1582344896 cites W2092045025 @default.
- W1582344896 cites W2094529805 @default.
- W1582344896 cites W2101326440 @default.
- W1582344896 cites W2105896802 @default.
- W1582344896 cites W2120971504 @default.
- W1582344896 cites W2125447402 @default.
- W1582344896 cites W2127755041 @default.
- W1582344896 cites W2146137488 @default.
- W1582344896 cites W2146785003 @default.
- W1582344896 cites W2147111300 @default.
- W1582344896 cites W2154090159 @default.
- W1582344896 cites W2156191468 @default.
- W1582344896 cites W2160256544 @default.
- W1582344896 cites W2163215914 @default.
- W1582344896 cites W2164610391 @default.
- W1582344896 cites W2167008898 @default.
- W1582344896 cites W2169387432 @default.
- W1582344896 cites W2181432100 @default.
- W1582344896 cites W2186713325 @default.
- W1582344896 cites W2395515826 @default.
- W1582344896 cites W2395657333 @default.
- W1582344896 cites W2403622654 @default.
- W1582344896 cites W2409163768 @default.
- W1582344896 cites W2415774753 @default.
- W1582344896 cites W2417140053 @default.
- W1582344896 cites W2471701661 @default.
- W1582344896 cites W2578350859 @default.
- W1582344896 cites W340804344 @default.
- W1582344896 cites W99113534 @default.
- W1582344896 cites W2409223595 @default.
- W1582344896 doi "https://doi.org/10.1159/000170936" @default.
- W1582344896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23689892" @default.
- W1582344896 hasPublicationYear "2013" @default.
- W1582344896 type Work @default.
- W1582344896 sameAs 1582344896 @default.
- W1582344896 citedByCount "5" @default.
- W1582344896 countsByYear W15823448962015 @default.
- W1582344896 countsByYear W15823448962017 @default.
- W1582344896 countsByYear W15823448962019 @default.
- W1582344896 countsByYear W15823448962020 @default.
- W1582344896 crossrefType "book-chapter" @default.
- W1582344896 hasAuthorship W1582344896A5009664981 @default.
- W1582344896 hasAuthorship W1582344896A5019076649 @default.
- W1582344896 hasAuthorship W1582344896A5037216277 @default.
- W1582344896 hasAuthorship W1582344896A5039902769 @default.
- W1582344896 hasAuthorship W1582344896A5065356926 @default.
- W1582344896 hasAuthorship W1582344896A5068058811 @default.
- W1582344896 hasAuthorship W1582344896A5072812686 @default.
- W1582344896 hasConcept C104317684 @default.
- W1582344896 hasConcept C147483822 @default.
- W1582344896 hasConcept C159047783 @default.
- W1582344896 hasConcept C159654299 @default.
- W1582344896 hasConcept C167508917 @default.
- W1582344896 hasConcept C195616568 @default.
- W1582344896 hasConcept C203014093 @default.
- W1582344896 hasConcept C2522874641 @default.
- W1582344896 hasConcept C2778359420 @default.