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• W1582393024 abstract "The p53 and nuclear factor κB (NF-κB) pathways play crucial roles in human cancer development. Simultaneous targeting of both pathways is an attractive therapeutic strategy against cancer. In this study, we report an antitumor molecule that bears a pyrrolo[3,4-c]pyrazole scaffold and functions as an enantiomeric inhibitor against both the p53-MDM2 interaction and the NF-κB activation. It is a first-in-class enantiomeric inhibitor with dual efficacy for cancer therapy. Synergistic effect was observed in vitro and in vivo. Docking and molecular dynamics simulation studies further provided insights into the nature of stereoselectivity." @default.
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• W1582393024 date "2014-10-07" @default.
• W1582393024 modified "2023-10-06" @default.
• W1582393024 title "A novel drug discovery strategy: Mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways" @default.
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• W1582393024 doi "https://doi.org/10.18632/oncotarget.2521" @default.
• W1582393024 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4279413" @default.
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