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- W1582417874 abstract "Xylazine-diazepam-ketamine (XDK) and xylazine-tiletamine-zolazepam (XTZ) have been always used for induction of anesthesia. There is no report regarding the effects of these anesthetics on the activated partial thromboplastin time (APTT), prothrombin time (PT) and platelet count (PLT) in horse. Therefore, this study has been conducted to search for the anesthetic combination less affecting the coagulation parameters in horses. Six healthy, mixed breed horses received XDK and XTZ anesthetic combinations at two weeks interval. Blood samples were collected before (baseline) and at 10, 30, 60 and 90 min after anesthesia and APTT, PT and PLT were measured. Although it was observed fluctuations in PT and APTT in both groups, it always remained within normal reference values of horse. In the XTZ group PLT decreased at 10 min, and increased at 60 min. On the other hand, PLT increased only at 10 min in the XDK group. There are no significant differences in PT, APTT and PLT values between groups. In conclusion, both anesthetics administration caused a fluctuation in the coagulation parameters. The small changes in these parameters are probably not clinically relevant, therefore these combinations can be used safely even in horses with coagulation disorders." @default.
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- W1582417874 date "2007-01-01" @default.
- W1582417874 modified "2023-10-13" @default.
- W1582417874 title "Effects of xylazine-diazepam-ketamine and xylazine-tiletamine-zolazepam anesthesia on some coagulation parameters in horses." @default.
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