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- W1582530932 abstract "Nerve growth factor (NGF) promotes neuronal differentiation of PC12 pheochromocytoma cells. We show here that within 5 min after its addition, NGF transiently stimulates c-fos proto-oncogene and actin transcription by greater than 100-fold in nonsynchronized PC12 cells. c-myc and ornithine decarboxylase transcription are also transiently activated, but more slowly. The corresponding mRNAs are induced as well. Two weeks' exposure to NGF causes no significant changes in the transcription of these and a variety of other genes analyzed; however, c-fos mRNA levels are increased severalfold under these conditions. Neuronally differentiated PC12 cells retain the capacity for rapid transcriptional responses. Removal of NGF from such cells for several hours followed by its readdition results in rapid induction of c-fos and actin transcription. These NGF-promoted transcriptional changes in PC12 cells are similar to those previously observed in quiescent fibroblasts stimulated by platelet-derived growth factor (Greenberg, M.E., and Ziff, E.B. (1984) Nature 311, 433-438). This rapid transcriptional activation in PC12 cells could be necessary for neuronal differentiation, but is apparently not sufficient since diverse agents without differentiating activity such as epidermal growth factor, insulin, dibutyryl cAMP, phorbol ester, and elevated K+ were also found to induce transcription. These results suggest that c-fos, c-myc, and actin induction may be general nuclear responses to growth or differentiation factors in a variety of different cell types." @default.
- W1582530932 created "2016-06-24" @default.
- W1582530932 creator A5018836890 @default.
- W1582530932 creator A5050331720 @default.
- W1582530932 creator A5068099853 @default.
- W1582530932 date "1985-11-01" @default.
- W1582530932 modified "2023-10-14" @default.
- W1582530932 title "Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells." @default.
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- W1582530932 doi "https://doi.org/10.1016/s0021-9258(17)38689-1" @default.
- W1582530932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3877054" @default.
- W1582530932 hasPublicationYear "1985" @default.
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