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- W1582591007 abstract "Work over the last few years had led to the recognition that a wide variety of heteroatomic polyaromatic hydrocarbons associated with fossil fuels or products of their use may act as genotoxins. The list of mutagens and potential carcinogens in direct coal liquefaction materials alone includes a variety of heteroatomic polycyclic aromatic hydrocarbons. This chapter reviews briefly some of what is known about the genetic activity of heteroatomic PAH, and illustrates how bioassays may be used along with chemical analysis to determine the principle agents responsible for such activity in complex mixtures associated with the processing and utilization of coal-based fossil fuels. The separation and analysis of heterocyclic PAH in complex mixtures, as well as what is known about their behavior in various in vitro tests for genotoxicity, is discussed. Chemical and in vitro data from both microbial and mammalian systems may be related to carcinogenesis as determined by long-term animal skin painting or by initiation/promotion assays. The possible utility of these data in arriving at an improved assessment of the potential health and environmental effects of a commercially deployed coal liquefaction industry is considered. Concentrations of nitrogen-containing compounds appear to correlate in many cases to the response for mostmore » of the in vitro results in these limited studies. The general body of data on chemical carcinogenesis is therefore being looked at to determine if heteroatomic species such as nitrogen containing polyaromatic compounds may be more important in the health and environmental effects of hydrocarbon pollutants than heretofore appreciated.« less" @default.
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- W1582591007 title "Heteroatomic polycyclic aromatic hydrocarbons in coal liquids. Rev" @default.
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