FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1582833276> ?p ?o ?g. }

• W1582833276 endingPage "420" @default.
• W1582833276 startingPage "411" @default.
• W1582833276 abstract "NF-κB is a transcription factor complex known for some time to play a pivotal role in the regulated expression of a large number of genes which are activated during an immune response. Antigen in the context of the appropriate antigen presenting cell (APC) leads to the proliferation of T cells and the expression of factors (predominantly cytokines) from the competent T cells. These factors in turn stimulate various cells involved in an immune response. Both the signal emanating from the initial antigenic encounter and the secondary factor-mediated responses in other cells involve NF-κB, at least in part. For example, NF-κB has been shown to be essential for the regulated expression of the immunoglobulin k light chain (whence the name NF-κB, a nuclear factor binding to the kappa light chain B element), the tumor necrosis factor alpha (TNF-α) and beta (TNF-β), interferon-β, the IL-2 receptor, the IL-6 cytokine, the IL-2 growth factor, GM-CSF, G-CSF, and MHC-Class I, just to name a few immunomodulatory gene products. NF-κB is implicated also in the induction of various acute phase proteins (e.g. angiotensinogen), some transcription factors/oncogenes (e.g. IRF-1 and c-myc) and, most importantly, in the induction of various viruses, including the human immunodeficiency virus (HIV), cytomegalovirus, adenovirus and SV40. NF-κB mediates its effects through so-called κB elements; the consensus sequence for a κB site reads GGGRNNYYCC, but additional variants exist to which NF-κB binds. A variety of agents as well as factors produced by stimulated cells activate NF-κB in the respective target cells; included among these are a large array of T cell mitogens (e.g. lectins, anti CD3 and anti CD2 antibodies, in addition to antigen/APC), the factors TNF-α and TNF-β, IL-1, double-stranded RNA, chemical agents which cause PKC activation, DNA damaging agents and treatments which produce oxygen radicals. In addition, several viruses have been shown to cause NF-κB activation like the HTLV-I and -II viruses, the HSV-1 virus, the HHV-6 virus, the Hepatitis B virus and the adenovirus. These viruses apparently subvert the cellular mechanisms to induce an activation phenotype in cells. The listing given here for agents which activate NF-κB and for genes regulated by NF-κB is only a partial one and is only meant to convey the central role this transcription factor plays during cellular activation and, in particular, during immune activation (for a complete listing and the appropriate References see recent reviews [1, 2])." @default.
• W1582833276 created "2016-06-24" @default.
• W1582833276 creator A5009843959 @default.
• W1582833276 creator A5017597678 @default.
• W1582833276 creator A5045851094 @default.
• W1582833276 creator A5050359150 @default.
• W1582833276 creator A5050535039 @default.
• W1582833276 creator A5077528679 @default.
• W1582833276 creator A5083510035 @default.
• W1582833276 creator A5085115963 @default.
• W1582833276 date "1992-01-01" @default.
• W1582833276 modified "2023-09-24" @default.
• W1582833276 title "Lymphocyte Activation and the Family of NF-κB Transcription Factor Complexes" @default.
• W1582833276 cites W143133239 @default.
• W1582833276 cites W1568529372 @default.
• W1582833276 cites W157084603 @default.
• W1582833276 cites W1603650405 @default.
• W1582833276 cites W1664043066 @default.
• W1582833276 cites W1756169576 @default.
• W1582833276 cites W1840764472 @default.
• W1582833276 cites W1850326393 @default.
• W1582833276 cites W1891648127 @default.
• W1582833276 cites W1963687107 @default.
• W1582833276 cites W1964596759 @default.
• W1582833276 cites W1964960571 @default.
• W1582833276 cites W1965168699 @default.
• W1582833276 cites W1973562827 @default.
• W1582833276 cites W1977348907 @default.
• W1582833276 cites W1982044167 @default.
• W1582833276 cites W1988876993 @default.
• W1582833276 cites W1991606993 @default.
• W1582833276 cites W1997988665 @default.
• W1582833276 cites W1999261530 @default.
• W1582833276 cites W2005484362 @default.
• W1582833276 cites W2006115758 @default.
• W1582833276 cites W2006929818 @default.
• W1582833276 cites W2017922713 @default.
• W1582833276 cites W2021869596 @default.
• W1582833276 cites W2027569621 @default.
• W1582833276 cites W2028376572 @default.
• W1582833276 cites W2029381336 @default.
• W1582833276 cites W2031208947 @default.
• W1582833276 cites W2032384795 @default.
• W1582833276 cites W2035278455 @default.
• W1582833276 cites W2035280748 @default.
• W1582833276 cites W2037928479 @default.
• W1582833276 cites W2042383781 @default.
• W1582833276 cites W2045793427 @default.
• W1582833276 cites W2047634049 @default.
• W1582833276 cites W2049781724 @default.
• W1582833276 cites W2051914105 @default.
• W1582833276 cites W2057120350 @default.
• W1582833276 cites W2059851697 @default.
• W1582833276 cites W2061903251 @default.
• W1582833276 cites W2061994720 @default.
• W1582833276 cites W2062800478 @default.
• W1582833276 cites W2063500485 @default.
• W1582833276 cites W2064767087 @default.
• W1582833276 cites W2068197542 @default.
• W1582833276 cites W2073784653 @default.
• W1582833276 cites W2073993982 @default.
• W1582833276 cites W2076854746 @default.
• W1582833276 cites W2083758347 @default.
• W1582833276 cites W2085236534 @default.
• W1582833276 cites W2088094960 @default.
• W1582833276 cites W2095248898 @default.
• W1582833276 cites W2095968188 @default.
• W1582833276 cites W2123102954 @default.
• W1582833276 cites W2124241283 @default.
• W1582833276 cites W2128508005 @default.
• W1582833276 cites W2159922116 @default.
• W1582833276 cites W2169989829 @default.
• W1582833276 cites W2170540477 @default.
• W1582833276 cites W2421037982 @default.
• W1582833276 cites W273960083 @default.
• W1582833276 cites W4237822095 @default.
• W1582833276 cites W4250655170 @default.
• W1582833276 cites W94282811 @default.
• W1582833276 doi "https://doi.org/10.1007/978-3-642-77633-5_52" @default.
• W1582833276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1490379" @default.
• W1582833276 hasPublicationYear "1992" @default.
• W1582833276 type Work @default.
• W1582833276 sameAs 1582833276 @default.
• W1582833276 citedByCount "16" @default.
• W1582833276 countsByYear W15828332762023 @default.
• W1582833276 crossrefType "book-chapter" @default.
• W1582833276 hasAuthorship W1582833276A5009843959 @default.
• W1582833276 hasAuthorship W1582833276A5017597678 @default.
• W1582833276 hasAuthorship W1582833276A5045851094 @default.
• W1582833276 hasAuthorship W1582833276A5050359150 @default.
• W1582833276 hasAuthorship W1582833276A5050535039 @default.
• W1582833276 hasAuthorship W1582833276A5077528679 @default.
• W1582833276 hasAuthorship W1582833276A5083510035 @default.
• W1582833276 hasAuthorship W1582833276A5085115963 @default.
• W1582833276 hasConcept C104317684 @default.
• W1582833276 hasConcept C147483822 @default.
• W1582833276 hasConcept C153911025 @default.
• W1582833276 hasConcept C17991360 @default.

• next