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- W1582833462 endingPage "593" @default.
- W1582833462 startingPage "579" @default.
- W1582833462 abstract "Wound healing involves a series of carefully modulated steps, from initial injury and blood clot to the final reconstituted tissue or scar. A dynamic reciprocity exists throughout between the wound, blood elements, extracellular matrix, and cells that participate in healing. Multiple cytokines and signal transduction pathways regulate these reactions. A major component throughout most of the process is hyaluronan, a straight-chain carbohydrate extracellular matrix polymer. Hyaluronan occurs in multiple forms, chain length being the only distinguishing characteristic between them. Levels of hyaluronan in its high–molecular-weight form are prominent in the earliest stages of wound repair. Progressively more fragmented forms occur in a manner not previously appreciated. We outline here steps in the wound healing cascade in which hyaluronan participates, as well as providing a review of its metabolism. Although described by necessity in a series of quantum steps, the healing process is constituted by a smooth continuum of overlapping reactions. The prevalence of hyaluronan in the wound (initially termed “hexosamine-containing mucopolysaccharide”), particularly in its early stages, was pointed out over half a century ago by the Harvard surgeon J. Engelbert Dunphy. It appears we are now returning to where we started." @default.
- W1582833462 created "2016-06-24" @default.
- W1582833462 creator A5012564952 @default.
- W1582833462 creator A5069679311 @default.
- W1582833462 date "2014-09-01" @default.
- W1582833462 modified "2023-10-10" @default.
- W1582833462 title "Hyaluronan in wound healing: Rediscovering a major player" @default.
- W1582833462 cites W108575403 @default.
- W1582833462 cites W1589578796 @default.
- W1582833462 cites W1591053360 @default.
- W1582833462 cites W1903604055 @default.
- W1582833462 cites W1935332540 @default.
- W1582833462 cites W1964179595 @default.
- W1582833462 cites W1966422114 @default.
- W1582833462 cites W1969250152 @default.
- W1582833462 cites W1970518941 @default.
- W1582833462 cites W1973769178 @default.
- W1582833462 cites W1974796552 @default.
- W1582833462 cites W1976646654 @default.
- W1582833462 cites W1977782939 @default.
- W1582833462 cites W1979458027 @default.
- W1582833462 cites W1979852216 @default.
- W1582833462 cites W1979907936 @default.
- W1582833462 cites W1981685424 @default.
- W1582833462 cites W1981977662 @default.
- W1582833462 cites W1983020647 @default.
- W1582833462 cites W1983829047 @default.
- W1582833462 cites W1983883185 @default.
- W1582833462 cites W1984962971 @default.
- W1582833462 cites W1985193039 @default.
- W1582833462 cites W1987893498 @default.
- W1582833462 cites W1988527057 @default.
- W1582833462 cites W1988622687 @default.
- W1582833462 cites W1988760595 @default.
- W1582833462 cites W1994527727 @default.
- W1582833462 cites W1998531407 @default.
- W1582833462 cites W2002632026 @default.
- W1582833462 cites W2003380614 @default.
- W1582833462 cites W2004526409 @default.
- W1582833462 cites W2005985941 @default.
- W1582833462 cites W2006721421 @default.
- W1582833462 cites W2007035508 @default.
- W1582833462 cites W2007129300 @default.
- W1582833462 cites W2008835126 @default.
- W1582833462 cites W2009105615 @default.
- W1582833462 cites W2010404817 @default.
- W1582833462 cites W2013288351 @default.
- W1582833462 cites W2015150804 @default.
- W1582833462 cites W2015472266 @default.
- W1582833462 cites W2019268059 @default.
- W1582833462 cites W2021423422 @default.
- W1582833462 cites W2021564917 @default.
- W1582833462 cites W2023692761 @default.
- W1582833462 cites W2024335985 @default.
- W1582833462 cites W2027375557 @default.
- W1582833462 cites W2033359020 @default.
- W1582833462 cites W2033677151 @default.
- W1582833462 cites W2034285920 @default.
- W1582833462 cites W2034347152 @default.
- W1582833462 cites W2035536358 @default.
- W1582833462 cites W2037348497 @default.
- W1582833462 cites W2038372277 @default.
- W1582833462 cites W2038555542 @default.
- W1582833462 cites W2041356122 @default.
- W1582833462 cites W2041654773 @default.
- W1582833462 cites W2043366026 @default.
- W1582833462 cites W2043958179 @default.
- W1582833462 cites W2045083218 @default.
- W1582833462 cites W2045973674 @default.
- W1582833462 cites W2046799161 @default.
- W1582833462 cites W2048635083 @default.
- W1582833462 cites W2048954730 @default.
- W1582833462 cites W2049460207 @default.
- W1582833462 cites W2050644549 @default.
- W1582833462 cites W2053272547 @default.
- W1582833462 cites W2053802748 @default.
- W1582833462 cites W2059243828 @default.
- W1582833462 cites W2061095488 @default.
- W1582833462 cites W2061626698 @default.
- W1582833462 cites W2061980960 @default.
- W1582833462 cites W2062003642 @default.
- W1582833462 cites W2062141712 @default.
- W1582833462 cites W2062622246 @default.
- W1582833462 cites W2063386669 @default.
- W1582833462 cites W2063795678 @default.
- W1582833462 cites W2064183925 @default.
- W1582833462 cites W2065159693 @default.
- W1582833462 cites W2070974310 @default.
- W1582833462 cites W2071167287 @default.
- W1582833462 cites W2071589283 @default.
- W1582833462 cites W2073214088 @default.
- W1582833462 cites W2077209593 @default.
- W1582833462 cites W2077631718 @default.
- W1582833462 cites W2078136797 @default.
- W1582833462 cites W2078504572 @default.
- W1582833462 cites W2078921003 @default.
- W1582833462 cites W2085665189 @default.
- W1582833462 cites W2088128469 @default.