FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W158285355> ?p ?o ?g. }

• W158285355 endingPage "2075" @default.
• W158285355 startingPage "2067" @default.
• W158285355 abstract "Research Article1 July 1989free access Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast. J. R. Mullen J. R. Mullen Department of Biochemistry, State University of New York, Stony Brook 11794. Search for more papers by this author P. S. Kayne P. S. Kayne Department of Biochemistry, State University of New York, Stony Brook 11794. Search for more papers by this author R. P. Moerschell R. P. Moerschell Department of Biochemistry, State University of New York, Stony Brook 11794. Search for more papers by this author S. Tsunasawa S. Tsunasawa Department of Biochemistry, State University of New York, Stony Brook 11794. Search for more papers by this author M. Gribskov M. Gribskov Department of Biochemistry, State University of New York, Stony Brook 11794. Search for more papers by this author M. Colavito-Shepanski M. Colavito-Shepanski Department of Biochemistry, State University of New York, Stony Brook 11794. Search for more papers by this author M. Grunstein M. Grunstein Department of Biochemistry, State University of New York, Stony Brook 11794. Search for more papers by this author F. Sherman F. Sherman Department of Biochemistry, State University of New York, Stony Brook 11794. Search for more papers by this author R. Sternglanz R. Sternglanz Department of Biochemistry, State University of New York, Stony Brook 11794. Search for more papers by this author J. R. Mullen J. R. Mullen Department of Biochemistry, State University of New York, Stony Brook 11794. Search for more papers by this author P. S. Kayne P. S. Kayne Department of Biochemistry, State University of New York, Stony Brook 11794. Search for more papers by this author R. P. Moerschell R. P. Moerschell Department of Biochemistry, State University of New York, Stony Brook 11794. Search for more papers by this author S. Tsunasawa S. Tsunasawa Department of Biochemistry, State University of New York, Stony Brook 11794. Search for more papers by this author M. Gribskov M. Gribskov Department of Biochemistry, State University of New York, Stony Brook 11794. Search for more papers by this author M. Colavito-Shepanski M. Colavito-Shepanski Department of Biochemistry, State University of New York, Stony Brook 11794. Search for more papers by this author M. Grunstein M. Grunstein Department of Biochemistry, State University of New York, Stony Brook 11794. Search for more papers by this author F. Sherman F. Sherman Department of Biochemistry, State University of New York, Stony Brook 11794. Search for more papers by this author R. Sternglanz R. Sternglanz Department of Biochemistry, State University of New York, Stony Brook 11794. Search for more papers by this author Author Information J. R. Mullen1, P. S. Kayne1, R. P. Moerschell1, S. Tsunasawa1, M. Gribskov1, M. Colavito-Shepanski1, M. Grunstein1, F. Sherman1 and R. Sternglanz1 1Department of Biochemistry, State University of New York, Stony Brook 11794. The EMBO Journal (1989)8:2067-2075https://doi.org/10.1002/j.1460-2075.1989.tb03615.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info A gene from Saccharomyces cerevisiae has been mapped, cloned, sequenced and shown to encode a catalytic subunit of an N-terminal acetyltransferase. Regions of this gene, NAT1, and the chloramphenicol acetyltransferase genes of bacteria have limited but significant homology. A nat1 null mutant is viable but exhibits a variety of phenotypes, including reduced acetyltransferase activity, derepression of a silent mating type locus (HML) and failure to enter G0. All these phenotypes are identical to those of a previously characterized mutant, ard1. NAT1 and ARD1 are distinct genes that encode proteins with no obvious similarity. Concomitant overexpression of both NAT1 and ARD1 in yeast causes a 20-fold increase in acetyltransferase activity in vitro, whereas overexpression of either NAT1 or ARD1 alone does not raise activity over basal levels. A functional iso-1-cytochrome c protein, which is N-terminally acetylated in a NAT1 strain, is not acetylated in an isogenic nat1 mutant. At least 20 other yeast proteins, including histone H2B, are not N-terminally acetylated in either nat1 or ard1 mutants. These results suggest that NAT1 and ARD1 proteins function together to catalyze the N-terminal acetylation of a subset of yeast proteins. Previous ArticleNext Article Volume 8Issue 71 July 1989In this issue RelatedDetailsLoading ..." @default.
• W158285355 created "2016-06-24" @default.
• W158285355 creator A5009277332 @default.
• W158285355 creator A5009453365 @default.
• W158285355 creator A5032073050 @default.
• W158285355 creator A5039922974 @default.
• W158285355 creator A5056614311 @default.
• W158285355 creator A5060014685 @default.
• W158285355 creator A5069405349 @default.
• W158285355 creator A5077498569 @default.
• W158285355 creator A5078623413 @default.
• W158285355 date "1989-07-01" @default.
• W158285355 modified "2023-10-18" @default.
• W158285355 title "Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast." @default.
• W158285355 cites W1505269918 @default.
• W158285355 cites W1511436795 @default.
• W158285355 cites W1525267478 @default.
• W158285355 cites W1537782690 @default.
• W158285355 cites W1557428740 @default.
• W158285355 cites W1562956043 @default.
• W158285355 cites W1566158288 @default.
• W158285355 cites W1572932807 @default.
• W158285355 cites W1575868449 @default.
• W158285355 cites W1593201653 @default.
• W158285355 cites W168383662 @default.
• W158285355 cites W1752502457 @default.
• W158285355 cites W1764442744 @default.
• W158285355 cites W1775749144 @default.
• W158285355 cites W1811297709 @default.
• W158285355 cites W1846763343 @default.
• W158285355 cites W1855498923 @default.
• W158285355 cites W1890540548 @default.
• W158285355 cites W1902685772 @default.
• W158285355 cites W1929236293 @default.
• W158285355 cites W1967419673 @default.
• W158285355 cites W1968916548 @default.
• W158285355 cites W1969051510 @default.
• W158285355 cites W1974061652 @default.
• W158285355 cites W1984750219 @default.
• W158285355 cites W1987045539 @default.
• W158285355 cites W1990157475 @default.
• W158285355 cites W2003798106 @default.
• W158285355 cites W2008014792 @default.
• W158285355 cites W2009155883 @default.
• W158285355 cites W2013554145 @default.
• W158285355 cites W2017139247 @default.
• W158285355 cites W2027434585 @default.
• W158285355 cites W2030288452 @default.
• W158285355 cites W2034277598 @default.
• W158285355 cites W2034939386 @default.
• W158285355 cites W2039833404 @default.
• W158285355 cites W2045911190 @default.
• W158285355 cites W2049488119 @default.
• W158285355 cites W2052562460 @default.
• W158285355 cites W2054400465 @default.
• W158285355 cites W2057323838 @default.
• W158285355 cites W2065723356 @default.
• W158285355 cites W2074413100 @default.
• W158285355 cites W2076300996 @default.
• W158285355 cites W2077112315 @default.
• W158285355 cites W2079827423 @default.
• W158285355 cites W2079901091 @default.
• W158285355 cites W2102536188 @default.
• W158285355 cites W2114217399 @default.
• W158285355 cites W2138270253 @default.
• W158285355 cites W2148943754 @default.
• W158285355 cites W2153477621 @default.
• W158285355 doi "https://doi.org/10.1002/j.1460-2075.1989.tb03615.x" @default.
• W158285355 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/401092" @default.
• W158285355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2551674" @default.
• W158285355 hasPublicationYear "1989" @default.
• W158285355 type Work @default.
• W158285355 sameAs 158285355 @default.
• W158285355 citedByCount "312" @default.
• W158285355 countsByYear W1582853552012 @default.
• W158285355 countsByYear W1582853552013 @default.
• W158285355 countsByYear W1582853552014 @default.
• W158285355 countsByYear W1582853552015 @default.
• W158285355 countsByYear W1582853552016 @default.
• W158285355 countsByYear W1582853552017 @default.
• W158285355 countsByYear W1582853552018 @default.
• W158285355 countsByYear W1582853552019 @default.
• W158285355 countsByYear W1582853552020 @default.
• W158285355 countsByYear W1582853552021 @default.
• W158285355 countsByYear W1582853552022 @default.
• W158285355 countsByYear W1582853552023 @default.
• W158285355 crossrefType "journal-article" @default.
• W158285355 hasAuthorship W158285355A5009277332 @default.
• W158285355 hasAuthorship W158285355A5009453365 @default.
• W158285355 hasAuthorship W158285355A5032073050 @default.
• W158285355 hasAuthorship W158285355A5039922974 @default.
• W158285355 hasAuthorship W158285355A5056614311 @default.
• W158285355 hasAuthorship W158285355A5060014685 @default.
• W158285355 hasAuthorship W158285355A5069405349 @default.
• W158285355 hasAuthorship W158285355A5077498569 @default.
• W158285355 hasAuthorship W158285355A5078623413 @default.
• W158285355 hasBestOaLocation W1582853551 @default.
• W158285355 hasConcept C11413529 @default.

• next