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• W1582854080 abstract "In reversal learning, subjects first learn to respond to a reinforced stimulus A and not to a non-reinforced stimulus B (A(+) vs. B(-)) and then have to learn the opposite when stimulus contingencies are reversed (A(-) vs. B(+)). This change in stimulus valence generates a transitory ambiguity at the level of stimulus outcome that needs to be overcome to solve the second discrimination. Honey bees (Apis mellifera) efficiently master reversal learning in the olfactory domain. The mushroom bodies (MBs), higher-order structures of the insect brain, are required to solve this task. Here we aimed at uncovering the neural circuits facilitating reversal learning in honey bees. We trained bees using the olfactory conditioning of the proboscis extension reflex (PER) coupled with localized pharmacological inhibition of Gamma-AminoButyric Acid (GABA)ergic signaling in the MBs. We show that inhibition of ionotropic but not metabotropic GABAergic signaling into the MB calyces impairs reversal learning, but leaves intact the capacity to perform two consecutive elemental olfactory discriminations with ambiguity of stimulus valence. On the contrary, inhibition of ionotropic GABAergic signaling into the MB lobes had no effect on reversal learning. Our results are thus consistent with a specific requirement of the feedback neurons (FNs) providing ionotropic GABAergic signaling from the MB lobes to the calyces for counteracting ambiguity of stimulus valence in reversal learning." @default.
• W1582854080 created "2016-06-24" @default.
• W1582854080 creator A5022615273 @default.
• W1582854080 creator A5023707904 @default.
• W1582854080 creator A5057057265 @default.
• W1582854080 creator A5060237609 @default.
• W1582854080 date "2015-07-29" @default.
• W1582854080 modified "2023-10-01" @default.
• W1582854080 title "GABAergic feedback signaling into the calyces of the mushroom bodies enables olfactory reversal learning in honey bees" @default.
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• W1582854080 doi "https://doi.org/10.3389/fnbeh.2015.00198" @default.
• W1582854080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4518197" @default.
• W1582854080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26283938" @default.
• W1582854080 hasPublicationYear "2015" @default.
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