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- W1583068153 abstract "In vertebrates, symmetricversus asymmetric cleavage of β-carotene in the biosynthesis of vitamin A and its derivatives has been controversially discussed. Recently we have been able to identify a cDNA encoding a metazoan β,β-carotene-15,15′-dioxygenase from the fruit flyDrosophila melanogaster. This enzyme catalyzes the key step in vitamin A biosynthesis, symmetrically cleaving β-carotene to give two molecules of retinal. Mutations in the corresponding gene are known to lead to a blind, vitamin A-deficient phenotype. Orthologs of this enzyme have very recently been found also in vertebrates and molecularly characterized. Here we report the identification of a cDNA from mouse encoding a second type of carotene dioxygenase catalyzing exclusively the asymmetric oxidative cleavage of β-carotene at the 9′,10′ double bond of β-carotene and resulting in the formation of β-apo-10′-carotenal and β-ionone, a substance known as a floral scent from roses, for example. Besides β-carotene, lycopene is also oxidatively cleaved by the enzyme. The deduced amino acid sequence shares significant sequence identity with the β,β-carotene-15,15′-dioxygenases, and the two enzyme types have several conserved motifs. To establish its occurrence in different vertebrates, we then attempted and succeeded in cloning cDNAs encoding this new type of carotene dioxygenase from human and zebrafish as well. As regards their possible role, the apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects. Thus, in contrast toDrosophila, in vertebrates both symmetric and asymmetric cleavage pathways exist for carotenes, revealing a greater complexity of carotene metabolism." @default.
- W1583068153 created "2016-06-24" @default.
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- W1583068153 date "2001-04-01" @default.
- W1583068153 modified "2023-10-17" @default.
- W1583068153 title "Identification and Characterization of a Mammalian Enzyme Catalyzing the Asymmetric Oxidative Cleavage of Provitamin A" @default.
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- W1583068153 doi "https://doi.org/10.1074/jbc.m011510200" @default.
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