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- W1583074038 abstract "Significance Many viruses, including those of global concern, are dependent on internalization for their entry. We found that ribonuclease kappa (RNASEK) is required for infection of every virus we tested that enters cells through an acid-dependent pathway, including dengue, West Nile, Sindbis, Rift Valley Fever, and influenza viruses. Mechanistically, we found that RNASEK has no effect on virus binding to cells but, rather, is required for their uptake. RNASEK was required for diverse viruses that are dependent on clathrin-mediated endocytosis for entry, but we found that RNASEK was dispensable for general endocytic uptake. Therefore, RNASEK appears to play a unique role in viral uptake and may be a therapeutically viable target to inhibit major human viral pathogens." @default.
- W1583074038 created "2016-06-24" @default.
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- W1583074038 date "2015-06-08" @default.
- W1583074038 modified "2023-10-12" @default.
- W1583074038 title "RNASEK is required for internalization of diverse acid-dependent viruses" @default.
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- W1583074038 doi "https://doi.org/10.1073/pnas.1424098112" @default.
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