FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1583283620> ?p ?o ?g. }

• W1583283620 endingPage "6989" @default.
• W1583283620 startingPage "6984" @default.
• W1583283620 abstract "Abstract Human interleukin 4 (IL-4) specifically induces the low affinity receptor for IgE (Fc epsilon R2/CD23) on the surface of the Burkitt lymphoma cell line Jijoye. At 4 degrees C 125I-IL-4 specifically binds to high affinity receptors (Kd = 4-10 x 10(-11) M; Bmax, 600-1,200 sites/cell). Following a rapid temperature shift from 4 to 37 degrees C, 80% of the receptor-bound 125I-IL-4 disappeared from the cell surface within 20 min (t1/2 = 8.9 min). For every two internalized molecules of IL-4 (t1/2 = 13 min), one molecule of IL-4 dissociated from the cell surface (t1/2 = 25 min). More than 90% of the internalized IL-4 was released in a degraded form into the medium following first order kinetics (t1/2 = 68 min). Internalization was inhibited by cytoskeletal disrupting and lysosomotropic agents. Incubating cells with 1 nM IL-4 resulted in a rapid down-regulation of IL-4 receptors (75% loss after 2 h); a reexpression of receptor to control level occurred after 20 h in spite of the presence of a large excess of IL-4. Reexpression was delayed by chloroquine and blocked by cycloheximide and actinomycin D. By using the cross-linking agent bis(sulfosuccinimidyl)suberate, three polypeptides of Mr 130,000, 80,000, and 70,000 were specifically labeled with 125I-IL-4. These three polypeptides coordinately disappeared and reappeared with the 125I-IL-4 binding sites. The induction of Fc epsilon R2/CD23 required prolonged incubation (greater than 8 h) with IL-4 and thus may be dependent on the reexpression of IL-4 receptor." @default.
• W1583283620 created "2016-06-24" @default.
• W1583283620 creator A5002386378 @default.
• W1583283620 creator A5002962815 @default.
• W1583283620 creator A5010649793 @default.
• W1583283620 creator A5059303154 @default.
• W1583283620 creator A5063775354 @default.
• W1583283620 date "1989-04-01" @default.
• W1583283620 modified "2023-10-18" @default.
• W1583283620 title "Internalization of Human Interleukin 4 and Transient Down-regulation of Its Receptor in the CD23-inducible Jijoye Cells" @default.
• W1583283620 cites W1514777920 @default.
• W1583283620 cites W1527256831 @default.
• W1583283620 cites W1542487159 @default.
• W1583283620 cites W1542489867 @default.
• W1583283620 cites W1550951408 @default.
• W1583283620 cites W1551174843 @default.
• W1583283620 cites W1552059862 @default.
• W1583283620 cites W1553552126 @default.
• W1583283620 cites W1557835716 @default.
• W1583283620 cites W1560012131 @default.
• W1583283620 cites W1578441577 @default.
• W1583283620 cites W1589488717 @default.
• W1583283620 cites W167100554 @default.
• W1583283620 cites W1802120268 @default.
• W1583283620 cites W1840179691 @default.
• W1583283620 cites W1867679523 @default.
• W1583283620 cites W1959472468 @default.
• W1583283620 cites W1979492370 @default.
• W1583283620 cites W2032422012 @default.
• W1583283620 cites W2051772384 @default.
• W1583283620 cites W2064173499 @default.
• W1583283620 cites W2066289406 @default.
• W1583283620 cites W2068626888 @default.
• W1583283620 cites W2093107928 @default.
• W1583283620 cites W2100837269 @default.
• W1583283620 cites W2107027136 @default.
• W1583283620 cites W2115945544 @default.
• W1583283620 cites W2119338471 @default.
• W1583283620 cites W2123733931 @default.
• W1583283620 cites W2125753847 @default.
• W1583283620 cites W2126181905 @default.
• W1583283620 cites W2158558560 @default.
• W1583283620 cites W2163674519 @default.
• W1583283620 cites W2165644577 @default.
• W1583283620 cites W2167948410 @default.
• W1583283620 cites W2171009645 @default.
• W1583283620 doi "https://doi.org/10.1016/s0021-9258(18)83528-1" @default.
• W1583283620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2523386" @default.
• W1583283620 hasPublicationYear "1989" @default.
• W1583283620 type Work @default.
• W1583283620 sameAs 1583283620 @default.
• W1583283620 citedByCount "60" @default.
• W1583283620 countsByYear W15832836202016 @default.
• W1583283620 countsByYear W15832836202017 @default.
• W1583283620 countsByYear W15832836202019 @default.
• W1583283620 countsByYear W15832836202021 @default.
• W1583283620 crossrefType "journal-article" @default.
• W1583283620 hasAuthorship W1583283620A5002386378 @default.
• W1583283620 hasAuthorship W1583283620A5002962815 @default.
• W1583283620 hasAuthorship W1583283620A5010649793 @default.
• W1583283620 hasAuthorship W1583283620A5059303154 @default.
• W1583283620 hasAuthorship W1583283620A5063775354 @default.
• W1583283620 hasBestOaLocation W15832836201 @default.
• W1583283620 hasConcept C111919701 @default.
• W1583283620 hasConcept C139770010 @default.
• W1583283620 hasConcept C141105273 @default.
• W1583283620 hasConcept C159654299 @default.
• W1583283620 hasConcept C170493617 @default.
• W1583283620 hasConcept C185592680 @default.
• W1583283620 hasConcept C203014093 @default.
• W1583283620 hasConcept C2780799671 @default.
• W1583283620 hasConcept C34814297 @default.
• W1583283620 hasConcept C41008148 @default.
• W1583283620 hasConcept C55493867 @default.
• W1583283620 hasConcept C86803240 @default.
• W1583283620 hasConcept C95444343 @default.
• W1583283620 hasConceptScore W1583283620C111919701 @default.
• W1583283620 hasConceptScore W1583283620C139770010 @default.
• W1583283620 hasConceptScore W1583283620C141105273 @default.
• W1583283620 hasConceptScore W1583283620C159654299 @default.
• W1583283620 hasConceptScore W1583283620C170493617 @default.
• W1583283620 hasConceptScore W1583283620C185592680 @default.
• W1583283620 hasConceptScore W1583283620C203014093 @default.
• W1583283620 hasConceptScore W1583283620C2780799671 @default.
• W1583283620 hasConceptScore W1583283620C34814297 @default.
• W1583283620 hasConceptScore W1583283620C41008148 @default.
• W1583283620 hasConceptScore W1583283620C55493867 @default.
• W1583283620 hasConceptScore W1583283620C86803240 @default.
• W1583283620 hasConceptScore W1583283620C95444343 @default.
• W1583283620 hasIssue "12" @default.
• W1583283620 hasLocation W15832836201 @default.
• W1583283620 hasOpenAccess W1583283620 @default.
• W1583283620 hasPrimaryLocation W15832836201 @default.
• W1583283620 hasRelatedWork W1807798123 @default.
• W1583283620 hasRelatedWork W1965030380 @default.
• W1583283620 hasRelatedWork W2068721292 @default.
• W1583283620 hasRelatedWork W2089485890 @default.
• W1583283620 hasRelatedWork W2145545797 @default.

• next