Matches in SemOpenAlex for { <https://semopenalex.org/work/W1583359894> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W1583359894 endingPage "2299" @default.
- W1583359894 startingPage "2291" @default.
- W1583359894 abstract "Abstract Human peripheral blood lymphocytes heated at 45 degrees C for 1 hr were found to continue to express all the serologically detected class II MHC antigens (HLA DR, MT, MB) but not to stimulate proliferation in primary or secondary MLR. Such cells did, however, stimulate the formation of potent suppressor cells. Three additional stimulator cell models for the presentation of either class I antigen only (purified platelets and purified T cells) or class I antigen plus nonimmunogenic class II antigen (D/DR-compatible cells) gave identical results. Supernatants from cultures stimulated with any of these cell types had significantly reduced IL 2 activity when compared to control MLR. The suppressor cells generated in such cultures were not restricted to the class I or class II MHC antigen of the original stimulator. These data are interpreted to mean that 1) the class II epitopes detected by alloantisera and the epitopes that serve as lymphocyte-activating determinants are metabolically or conformationally distinct, and 2) that presentation of class I MHC antigen alone or in conjunction with nonimmunogenic class II MHC antigen preferentially stimulates the formation of suppressor cells. It is hypothesized that the latter may be an additional mechanism that contributes to the efficacy of matching for class II determinants in human renal transplantation." @default.
- W1583359894 created "2016-06-24" @default.
- W1583359894 creator A5000848639 @default.
- W1583359894 date "1984-05-01" @default.
- W1583359894 modified "2023-10-12" @default.
- W1583359894 title "Human suppressor cell induction in vitro: preferential activation by class I MHC antigen." @default.
- W1583359894 doi "https://doi.org/10.4049/jimmunol.132.5.2291" @default.
- W1583359894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6232315" @default.
- W1583359894 hasPublicationYear "1984" @default.
- W1583359894 type Work @default.
- W1583359894 sameAs 1583359894 @default.
- W1583359894 citedByCount "12" @default.
- W1583359894 crossrefType "journal-article" @default.
- W1583359894 hasAuthorship W1583359894A5000848639 @default.
- W1583359894 hasBestOaLocation W15833598941 @default.
- W1583359894 hasConcept C108249834 @default.
- W1583359894 hasConcept C147483822 @default.
- W1583359894 hasConcept C153911025 @default.
- W1583359894 hasConcept C154317977 @default.
- W1583359894 hasConcept C170627219 @default.
- W1583359894 hasConcept C188280979 @default.
- W1583359894 hasConcept C195616568 @default.
- W1583359894 hasConcept C197695756 @default.
- W1583359894 hasConcept C202751555 @default.
- W1583359894 hasConcept C203014093 @default.
- W1583359894 hasConcept C207936829 @default.
- W1583359894 hasConcept C2776090121 @default.
- W1583359894 hasConcept C2778740727 @default.
- W1583359894 hasConcept C2778814158 @default.
- W1583359894 hasConcept C55493867 @default.
- W1583359894 hasConcept C83464605 @default.
- W1583359894 hasConcept C86803240 @default.
- W1583359894 hasConcept C8891405 @default.
- W1583359894 hasConceptScore W1583359894C108249834 @default.
- W1583359894 hasConceptScore W1583359894C147483822 @default.
- W1583359894 hasConceptScore W1583359894C153911025 @default.
- W1583359894 hasConceptScore W1583359894C154317977 @default.
- W1583359894 hasConceptScore W1583359894C170627219 @default.
- W1583359894 hasConceptScore W1583359894C188280979 @default.
- W1583359894 hasConceptScore W1583359894C195616568 @default.
- W1583359894 hasConceptScore W1583359894C197695756 @default.
- W1583359894 hasConceptScore W1583359894C202751555 @default.
- W1583359894 hasConceptScore W1583359894C203014093 @default.
- W1583359894 hasConceptScore W1583359894C207936829 @default.
- W1583359894 hasConceptScore W1583359894C2776090121 @default.
- W1583359894 hasConceptScore W1583359894C2778740727 @default.
- W1583359894 hasConceptScore W1583359894C2778814158 @default.
- W1583359894 hasConceptScore W1583359894C55493867 @default.
- W1583359894 hasConceptScore W1583359894C83464605 @default.
- W1583359894 hasConceptScore W1583359894C86803240 @default.
- W1583359894 hasConceptScore W1583359894C8891405 @default.
- W1583359894 hasIssue "5" @default.
- W1583359894 hasLocation W15833598941 @default.
- W1583359894 hasLocation W15833598942 @default.
- W1583359894 hasOpenAccess W1583359894 @default.
- W1583359894 hasPrimaryLocation W15833598941 @default.
- W1583359894 hasRelatedWork W1548452743 @default.
- W1583359894 hasRelatedWork W1999436383 @default.
- W1583359894 hasRelatedWork W2068467835 @default.
- W1583359894 hasRelatedWork W2089374733 @default.
- W1583359894 hasRelatedWork W2118222952 @default.
- W1583359894 hasRelatedWork W2120625126 @default.
- W1583359894 hasRelatedWork W2355173120 @default.
- W1583359894 hasRelatedWork W2356382702 @default.
- W1583359894 hasRelatedWork W2461685090 @default.
- W1583359894 hasRelatedWork W310150535 @default.
- W1583359894 hasVolume "132" @default.
- W1583359894 isParatext "false" @default.
- W1583359894 isRetracted "false" @default.
- W1583359894 magId "1583359894" @default.
- W1583359894 workType "article" @default.