FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W158339772> ?p ?o ?g. }

• W158339772 endingPage "32" @default.
• W158339772 startingPage "15" @default.
• W158339772 abstract "Studies to determine the etiology of osteosarcoma involve epidemiologic and environmental factors and genetic impairments. Factors related to patient characteristics include age, gender, ethnicity, growth and height, genetic and familial factors, and preexisting bone abnormalities. Rapidly proliferating cells may be particularly susceptible to oncogenic agents and mitotic errors which lead to neoplastic transformation. Genetic aberrations that accompany osteosarcoma have received increasing recognition as an important factor in its etiology. Osteosarcoma tumor cells exhibit karyotypes with a high degree of complexity which has made it difficult to determine whether any recurrent chromosomal aberrations characterize osteosarcoma. Although extremely rare, osteosarcoma has occasionally been observed in several members of the same family. No other clinical abnormalities in the proband or the affected members were reported. Pathologic examination of the tumors revealed no unusual features. Genetic testing was not available in most of these reports. The patients generally responded to conventional therapy. A genetic predisposition to osteosarcoma is found in patients with hereditary retinoblastoma, characterized by mutation of the retinoblastoma gene RB1 on chromosome 13q14. The Rothmund-Thomson syndrome is an autosomal recessive disorder with a heterogeneous clinical profile. Patients may have a few or multiple clinical features including skin rash, small stature, skeletal dysplasias, sparse or absent scalp hair, eyebrows or eyelashes, juvenile cataracts, and gastrointestinal disturbance including chronic emesis and diarrhea; its molecular basis is the mutation in the RECQL4 gene in a subset of cases. The Li-Fraumeni syndrome is an autosomal dominant disorder characterized by a high risk of developing osteosarcoma and has been found in up to 3% of children with osteosarcoma. It is associated with a germline mutation of the p53, a suppressor gene. The following three criteria must be met for a diagnosis of Li-Fraumeni syndrome: (1) A proband diagnosed with sarcoma when younger than 45 years; (2) A first-degree relative with any cancer diagnosed when younger than 45 years; (3) Another first- or second-degree relative of the same genetic lineage with any cancer diagnosed when younger than 45 years or sarcoma diagnosed at any age. A second recessive p53 oncogene on chromosome 17p13.1 may also play a role in the development and progression of osteosarcoma. Osteosarcoma has also been associated with solitary or multiple osteochondroma, solitary enchondroma or enchondromatosis (Ollier's disease), multiple hereditary exostoses, fibrous dysplasia, chronic osteomyelitis, sites of bone infarcts, sites of metallic prostheses and sites of prior internal fixation. Ionizing radiation is a well-documented etiologic factor. Osteosarcoma has also been associated with the use of intravenous radium and Thorotrast. Exposure to alkylating agents may also contribute to its development ,and it is apparently independent of the administration of radiotherapy." @default.
• W158339772 created "2016-06-24" @default.
• W158339772 creator A5003536492 @default.
• W158339772 creator A5062270706 @default.
• W158339772 date "2009-01-01" @default.
• W158339772 modified "2023-10-03" @default.
• W158339772 title "The Etiology of Osteosarcoma" @default.
• W158339772 cites W1907124362 @default.
• W158339772 cites W1914608195 @default.
• W158339772 cites W1929571719 @default.
• W158339772 cites W1935801587 @default.
• W158339772 cites W1966552709 @default.
• W158339772 cites W1967436631 @default.
• W158339772 cites W1968329993 @default.
• W158339772 cites W1969766646 @default.
• W158339772 cites W1971494627 @default.
• W158339772 cites W1976426421 @default.
• W158339772 cites W1976696908 @default.
• W158339772 cites W1987073614 @default.
• W158339772 cites W1994157912 @default.
• W158339772 cites W1998778656 @default.
• W158339772 cites W2000259265 @default.
• W158339772 cites W2007023752 @default.
• W158339772 cites W2010078334 @default.
• W158339772 cites W2010632326 @default.
• W158339772 cites W2012103772 @default.
• W158339772 cites W2020436075 @default.
• W158339772 cites W2022473096 @default.
• W158339772 cites W2023399592 @default.
• W158339772 cites W2023719828 @default.
• W158339772 cites W2028340005 @default.
• W158339772 cites W2034282782 @default.
• W158339772 cites W2034393242 @default.
• W158339772 cites W2041973455 @default.
• W158339772 cites W2046207926 @default.
• W158339772 cites W2047287091 @default.
• W158339772 cites W2050249291 @default.
• W158339772 cites W2060658196 @default.
• W158339772 cites W2068158287 @default.
• W158339772 cites W2075037489 @default.
• W158339772 cites W2086105525 @default.
• W158339772 cites W2092946215 @default.
• W158339772 cites W2095918137 @default.
• W158339772 cites W2102203460 @default.
• W158339772 cites W2120582434 @default.
• W158339772 cites W2126201110 @default.
• W158339772 cites W2132413364 @default.
• W158339772 cites W2138819243 @default.
• W158339772 cites W2163208652 @default.
• W158339772 cites W2167083183 @default.
• W158339772 cites W2246379697 @default.
• W158339772 cites W2270331966 @default.
• W158339772 cites W2278456890 @default.
• W158339772 cites W2312726328 @default.
• W158339772 cites W2395256051 @default.
• W158339772 cites W2414199216 @default.
• W158339772 cites W2416774637 @default.
• W158339772 cites W2426636570 @default.
• W158339772 cites W296831189 @default.
• W158339772 cites W4211167801 @default.
• W158339772 cites W4295131891 @default.
• W158339772 cites W4302375634 @default.
• W158339772 doi "https://doi.org/10.1007/978-1-4419-0284-9_2" @default.
• W158339772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20213384" @default.
• W158339772 hasPublicationYear "2009" @default.
• W158339772 type Work @default.
• W158339772 sameAs 158339772 @default.
• W158339772 citedByCount "174" @default.
• W158339772 countsByYear W1583397722012 @default.
• W158339772 countsByYear W1583397722013 @default.
• W158339772 countsByYear W1583397722014 @default.
• W158339772 countsByYear W1583397722015 @default.
• W158339772 countsByYear W1583397722016 @default.
• W158339772 countsByYear W1583397722017 @default.
• W158339772 countsByYear W1583397722018 @default.
• W158339772 countsByYear W1583397722019 @default.
• W158339772 countsByYear W1583397722020 @default.
• W158339772 countsByYear W1583397722021 @default.
• W158339772 countsByYear W1583397722022 @default.
• W158339772 countsByYear W1583397722023 @default.
• W158339772 crossrefType "book-chapter" @default.
• W158339772 hasAuthorship W158339772A5003536492 @default.
• W158339772 hasAuthorship W158339772A5062270706 @default.
• W158339772 hasConcept C104317684 @default.
• W158339772 hasConcept C121608353 @default.
• W158339772 hasConcept C126322002 @default.
• W158339772 hasConcept C137627325 @default.
• W158339772 hasConcept C142724271 @default.
• W158339772 hasConcept C2776577112 @default.
• W158339772 hasConcept C2777760704 @default.
• W158339772 hasConcept C2777871287 @default.
• W158339772 hasConcept C54355233 @default.
• W158339772 hasConcept C71924100 @default.
• W158339772 hasConcept C86803240 @default.
• W158339772 hasConceptScore W158339772C104317684 @default.
• W158339772 hasConceptScore W158339772C121608353 @default.
• W158339772 hasConceptScore W158339772C126322002 @default.
• W158339772 hasConceptScore W158339772C137627325 @default.

• next