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• W1583461465 abstract "Cancer is the second deadliest disease in the United States. Over 100 different types of cancers exist, among which lung, breast and prostate cancers are those most frequently diagnosed. Genetic factors are important. However, exposures to tobacco smoke and environmental pollutants are considered to be responsible for 75%–80% of cancer. About 6% of cancer deaths every year in the US are reportedly to be directly linked to known carcinogen exposures. Therefore, it is important to study the mechanisms of how the environmental carcinogens trigger cancer initiation. Most chemical carcinogens are metabolized into reactive species in vivo to interact with DNA, consequently producing covalent DNA adducts. These harmful lesions can be removed by various repair systems including base excision and nucleotide excision repair machinery in the cell. However, unrepaired lesions can enter into cell’s DNA replication cycle and generate various point and frameshift mutations. In particular, the latter represents a gain or loss of base pairs, which alters the genome information. As an example, mutations on the specific genes such as the tumor suppressor p53 may trigger cancer initiation." @default.
• W1583461465 created "2016-06-24" @default.
• W1583461465 creator A5021310371 @default.
• W1583461465 date "2020-05-26" @default.
• W1583461465 modified "2023-09-26" @default.
• W1583461465 title "STRUCTURAL AND CONFORMATIONAL INSIGHTS INTO BULKY ARYLAMINE-INDUCED MUTAGENESIS" @default.
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• W1583461465 doi "https://doi.org/10.23860/diss-xu-lifang-2014" @default.
• W1583461465 hasPublicationYear "2020" @default.
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