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- W1583540134 abstract "The metabolism of Myleran has been investigated in an attempt to explain the mechanism of its biological action. After injection of Myleran into the rat, rabbit and mouse at least 60 per cent of the urinary radioactivity is in the form of 3-hydroxytetrahydrothiophene-1, 1-dioxide. S-β-l-alanyltetrahydrothiophenium mesylate, tetrahydrothiophene, and tetrahydrothiophene-1,1-dioxide are also metabolised to this compound. It is concluded that the major reaction which Myleran undergoes in vivo is reaction with cysteine or a cysteinyl moiety to form a cyclic sulphonium ion which undergoes decomposition to tetrahydrothiophene. This in turn is converted to tetrahydrothiophene-1, 1-dioxide and thence to 3-hydroxytetrahydrothiophene-1,1-dioxide." @default.
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- W1583540134 date "1961-06-01" @default.
- W1583540134 modified "2023-10-14" @default.
- W1583540134 title "The mode of action of alkylating agents—III" @default.
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- W1583540134 doi "https://doi.org/10.1016/0006-2952(61)90133-2" @default.
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