FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1583542819> ?p ?o ?g. }

• W1583542819 abstract "The Duplication-Degeneration-Complementation (DDC) model predicts that division of the original function between duplicate genes (subfunctionalization) is a common mechanism for their preservation. The Hox genes constitute a good system to test this hypothesis as they underwent significant expansion during evolution. Mammals have four Hox complexes whereas teleosts have additional complexes resulting from duplication event(s) that took place after the separation of the ray-finned and lobe-finned lineages. Thus, zebrafish and Takifugu have two hoxb complexes, each containing a hoxb5 gene. The zebrafish hoxbSa and hoxb5b genes are expressed in overlapping, yet distinct, domains during development with their combined expression patterns similar to that of the single mouse Hoxb5 gene. To determine if changes in cw-acting regulatory elements account for hoxb5a and hoxb5b subfunctionalization, we compared the sequences of the Hoxb5 loci of human, mouse, zebrafish and Takifugu and identified four conserved noncoding elements (CNEs). One of the CNEs, named J3, is only retained in the hoxb5a locus while three others are present in both teleost hoxb5 loci. We examined individual and collective regulatory activity of the CNEs in transgenic assays. When tested individually, the enhancer activity of individual cognate CNEs from the hoxb5a and hoxb5b genes extensively overlapped. In contrast, large fragments encompassing multiple CNEs were able to target reporter gene expression to unique domains of hoxb5a and hoxb5b expression. The deletion of J3 from the hoxb5a locus and its insertion in the hoxb5b locus drastically altered the regulatory activity of the original loci. Our results suggest that patterns of regulatory evolution of hoxbS duplicates in teleosts may be more complex than ones taken in consideration by the DDC model." @default.
• W1583542819 created "2016-06-24" @default.
• W1583542819 creator A5021052973 @default.
• W1583542819 date "2007-01-01" @default.
• W1583542819 modified "2023-09-28" @default.
• W1583542819 title "Molecular basis for functional diversification of duplicated hoxb5 genes in zebrafish" @default.
• W1583542819 cites W1484163259 @default.
• W1583542819 cites W1487395029 @default.
• W1583542819 cites W1497949622 @default.
• W1583542819 cites W1556520758 @default.
• W1583542819 cites W1602301410 @default.
• W1583542819 cites W1605682898 @default.
• W1583542819 cites W1823770435 @default.
• W1583542819 cites W1845773031 @default.
• W1583542819 cites W1868418021 @default.
• W1583542819 cites W1882773106 @default.
• W1583542819 cites W1889715612 @default.
• W1583542819 cites W1905840509 @default.
• W1583542819 cites W1913751214 @default.
• W1583542819 cites W1923477899 @default.
• W1583542819 cites W1938609092 @default.
• W1583542819 cites W1947231608 @default.
• W1583542819 cites W1952870715 @default.
• W1583542819 cites W1957995282 @default.
• W1583542819 cites W1965398846 @default.
• W1583542819 cites W1965682846 @default.
• W1583542819 cites W1970147973 @default.
• W1583542819 cites W1971170993 @default.
• W1583542819 cites W1976974916 @default.
• W1583542819 cites W1977294183 @default.
• W1583542819 cites W1977418399 @default.
• W1583542819 cites W1977687670 @default.
• W1583542819 cites W1980177621 @default.
• W1583542819 cites W1981946128 @default.
• W1583542819 cites W1982475981 @default.
• W1583542819 cites W1983553498 @default.
• W1583542819 cites W1986623296 @default.
• W1583542819 cites W1988246681 @default.
• W1583542819 cites W1992383169 @default.
• W1583542819 cites W1998020029 @default.
• W1583542819 cites W1999889695 @default.
• W1583542819 cites W2000026908 @default.
• W1583542819 cites W2002560720 @default.
• W1583542819 cites W2006788765 @default.
• W1583542819 cites W2009851083 @default.
• W1583542819 cites W2010261842 @default.
• W1583542819 cites W2013095276 @default.
• W1583542819 cites W2015162301 @default.
• W1583542819 cites W2016419622 @default.
• W1583542819 cites W2020048949 @default.
• W1583542819 cites W2023003508 @default.
• W1583542819 cites W2024776719 @default.
• W1583542819 cites W2031068703 @default.
• W1583542819 cites W2031112533 @default.
• W1583542819 cites W2031607357 @default.
• W1583542819 cites W2032620636 @default.
• W1583542819 cites W2033555181 @default.
• W1583542819 cites W2034459341 @default.
• W1583542819 cites W2034718537 @default.
• W1583542819 cites W2035299191 @default.
• W1583542819 cites W2043853830 @default.
• W1583542819 cites W2044251005 @default.
• W1583542819 cites W2047099342 @default.
• W1583542819 cites W2048249977 @default.
• W1583542819 cites W2049656130 @default.
• W1583542819 cites W2050296956 @default.
• W1583542819 cites W2052923559 @default.
• W1583542819 cites W2053626988 @default.
• W1583542819 cites W2059941285 @default.
• W1583542819 cites W2060929301 @default.
• W1583542819 cites W2061008107 @default.
• W1583542819 cites W2062474573 @default.
• W1583542819 cites W2064841986 @default.
• W1583542819 cites W2065528132 @default.
• W1583542819 cites W2066550987 @default.
• W1583542819 cites W2068281991 @default.
• W1583542819 cites W2071880700 @default.
• W1583542819 cites W2072035127 @default.
• W1583542819 cites W2072173923 @default.
• W1583542819 cites W2075862925 @default.
• W1583542819 cites W2077497255 @default.
• W1583542819 cites W2086005855 @default.
• W1583542819 cites W2088639474 @default.
• W1583542819 cites W2088769441 @default.
• W1583542819 cites W2090420516 @default.
• W1583542819 cites W2092139114 @default.
• W1583542819 cites W2092411127 @default.
• W1583542819 cites W2096860411 @default.
• W1583542819 cites W2100247616 @default.
• W1583542819 cites W2105207670 @default.
• W1583542819 cites W2105788966 @default.
• W1583542819 cites W2106753875 @default.
• W1583542819 cites W2106925853 @default.
• W1583542819 cites W2109042597 @default.
• W1583542819 cites W2116622696 @default.
• W1583542819 cites W2118218845 @default.
• W1583542819 cites W2119469219 @default.
• W1583542819 cites W2119666376 @default.
• W1583542819 cites W2120030937 @default.
• W1583542819 cites W2120960764 @default.

• next