FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1583558805> ?p ?o ?g. }

• W1583558805 endingPage "6517" @default.
• W1583558805 startingPage "6510" @default.
• W1583558805 abstract "The adherence of Plasmodium falciparum-infected RBC (IRBC) to postcapillary venular endothelium is an important determinant of the pathogenesis of severe malaria complications. Cytoadherence of IRBC to endothelial cells involves specific receptor/ligand interactions. The glycoprotein CD36 expressed on endothelial cells is the major receptor involved in this interaction. Treatment of CD36-expressing cells with reducing agents, such as DTT and N-acetylcysteine, was followed by CD36 conformational change monitorable by the appearance of the Mo91 mAb epitope. Only a fraction of the surface expressed CD36 molecules became Mo91 positive, suggesting the presence of two subpopulations of molecules with different sensitivities to reduction. The Mo91 epitope has been localized on a peptide (residues 260-279) of the C-terminal, cysteine-rich region of CD36. Treatment with reducing agents inhibited the CD36-dependent cytoadherence of IRBC to CD36-expressing cells and dissolved pre-existent CD36-mediated IRBC/CD36-expressing cell aggregates. CD36 reduction did not impair the functionality of CD36, since the reactivity of other anti-CD36 mAbs as well as the binding of oxidized low density lipoprotein, a CD36 ligand, were maintained. The modifications induced by reduction were reversible. After 14 h CD36 was reoxidized, the cells did not express the Mo91 epitope, and cytoadherence to IRBC was restored. The results indicate that IRBCs bind only to a redox-modulated fraction of CD36 molecules expressed on the cell surface. The present data indicate the therapeutic potential of reducing agents, such as the nontoxic drug N-acetylcysteine, to prevent or treat malaria complications due to IRBC cytoadhesion." @default.
• W1583558805 created "2016-06-24" @default.
• W1583558805 creator A5016071296 @default.
• W1583558805 creator A5038590830 @default.
• W1583558805 creator A5051012495 @default.
• W1583558805 creator A5054354287 @default.
• W1583558805 creator A5062777059 @default.
• W1583558805 creator A5070425551 @default.
• W1583558805 creator A5070466453 @default.
• W1583558805 creator A5089212521 @default.
• W1583558805 date "2001-12-01" @default.
• W1583558805 modified "2023-10-16" @default.
• W1583558805 title "Cytoadherence of <i>Plasmodium falciparum</i>-Infected Erythrocytes Is Mediated by a Redox-Dependent Conformational Fraction of CD36" @default.
• W1583558805 cites W13668240 @default.
• W1583558805 cites W150961072 @default.
• W1583558805 cites W1519857031 @default.
• W1583558805 cites W1586942665 @default.
• W1583558805 cites W1593705832 @default.
• W1583558805 cites W169321723 @default.
• W1583558805 cites W1933652297 @default.
• W1583558805 cites W1969599756 @default.
• W1583558805 cites W1970956968 @default.
• W1583558805 cites W1986985254 @default.
• W1583558805 cites W1990720074 @default.
• W1583558805 cites W1999332813 @default.
• W1583558805 cites W2006659499 @default.
• W1583558805 cites W2020251171 @default.
• W1583558805 cites W2020637870 @default.
• W1583558805 cites W2020847705 @default.
• W1583558805 cites W2020928512 @default.
• W1583558805 cites W2021874649 @default.
• W1583558805 cites W2022148560 @default.
• W1583558805 cites W2027989961 @default.
• W1583558805 cites W2030946376 @default.
• W1583558805 cites W2043418529 @default.
• W1583558805 cites W2043503050 @default.
• W1583558805 cites W2043873794 @default.
• W1583558805 cites W2045039384 @default.
• W1583558805 cites W2055515174 @default.
• W1583558805 cites W2059917880 @default.
• W1583558805 cites W2065510759 @default.
• W1583558805 cites W2078276534 @default.
• W1583558805 cites W2080494149 @default.
• W1583558805 cites W2088509118 @default.
• W1583558805 cites W2094912454 @default.
• W1583558805 cites W2124796800 @default.
• W1583558805 cites W2144481965 @default.
• W1583558805 cites W2144760773 @default.
• W1583558805 cites W2151928263 @default.
• W1583558805 cites W2156628356 @default.
• W1583558805 cites W2157603347 @default.
• W1583558805 cites W2159458795 @default.
• W1583558805 cites W2159790292 @default.
• W1583558805 cites W2163331958 @default.
• W1583558805 cites W2164245596 @default.
• W1583558805 cites W2224266189 @default.
• W1583558805 cites W2264469137 @default.
• W1583558805 cites W2266321115 @default.
• W1583558805 cites W2313265919 @default.
• W1583558805 cites W2333107025 @default.
• W1583558805 cites W2399282134 @default.
• W1583558805 cites W4235125537 @default.
• W1583558805 cites W4237567990 @default.
• W1583558805 cites W4245704039 @default.
• W1583558805 cites W4313347910 @default.
• W1583558805 doi "https://doi.org/10.4049/jimmunol.167.11.6510" @default.
• W1583558805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11714819" @default.
• W1583558805 hasPublicationYear "2001" @default.
• W1583558805 type Work @default.
• W1583558805 sameAs 1583558805 @default.
• W1583558805 citedByCount "22" @default.
• W1583558805 countsByYear W15835588052013 @default.
• W1583558805 countsByYear W15835588052015 @default.
• W1583558805 countsByYear W15835588052016 @default.
• W1583558805 countsByYear W15835588052018 @default.
• W1583558805 countsByYear W15835588052020 @default.
• W1583558805 countsByYear W15835588052021 @default.
• W1583558805 crossrefType "journal-article" @default.
• W1583558805 hasAuthorship W1583558805A5016071296 @default.
• W1583558805 hasAuthorship W1583558805A5038590830 @default.
• W1583558805 hasAuthorship W1583558805A5051012495 @default.
• W1583558805 hasAuthorship W1583558805A5054354287 @default.
• W1583558805 hasAuthorship W1583558805A5062777059 @default.
• W1583558805 hasAuthorship W1583558805A5070425551 @default.
• W1583558805 hasAuthorship W1583558805A5070466453 @default.
• W1583558805 hasAuthorship W1583558805A5089212521 @default.
• W1583558805 hasBestOaLocation W15835588051 @default.
• W1583558805 hasConcept C116569031 @default.
• W1583558805 hasConcept C147483822 @default.
• W1583558805 hasConcept C153911025 @default.
• W1583558805 hasConcept C159654299 @default.
• W1583558805 hasConcept C170493617 @default.
• W1583558805 hasConcept C185592680 @default.
• W1583558805 hasConcept C195616568 @default.
• W1583558805 hasConcept C203014093 @default.
• W1583558805 hasConcept C2778048844 @default.
• W1583558805 hasConcept C2778371730 @default.
• W1583558805 hasConcept C2779828298 @default.

• next