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- W1583622848 abstract "We have investigated if brain protein glia maturation factor (GMF) and Parkinson's disease (PD)-relevant toxin 1-methyl-4-phenylpyridinium (MPP+) and α-synuclein can activate mast cells to release inflammatory mediators. Mast cells are implicated and suggested as a therapeutic target in neuroinflammation but its role in PD is not yet understood. We have analyzed the effect of recombinant GMF, MPP+, α-synuclein and recombinant IL-33 on mouse bone marrow-derived cultured mast cells (BMMCs), human umbilical cord blood-derived cultured mast cells (hCBMCs), and mouse embryonic brain-derived cultured astrocytes. The release of cytokines/chemokines was determined by ELISA and the expression of co-stimulatory molecules CD40 and CD40Ligand by flow cytometry. GMF significantly released chemokine (C-C motif) ligand 2 (CCL2) from BMMCs when compared to un-treated control cells. GMF, α-synuclein and MPP+ activated BMMCs to release interleukin-1β (IL-1β), and IL-8 release from hCBMCs. IL-33, an IL-1 family member induced the expression of GMF in human mast cells. GMF induced more tumor necrosis factor-alpha (TNF-α) release from astrocyte- mast cell co-culture. Flow cytometry showed increased IL-33 expression by GMF and MPP+in astrocytes. GMF also induced the expression of CD40 in astrocytes. In conclusion, proinflammatory mediator release from mast cells following GMF, MPP+ or α-synuclein treatment, and significant release of GMF by mast cells indicate a novel drug target for neurodegenerative diseases including PD." @default.
- W1583622848 created "2016-06-24" @default.
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- W1583622848 date "2015-04-01" @default.
- W1583622848 modified "2023-09-23" @default.
- W1583622848 title "Glia Maturation Factor Stimulates Release of Proinflammatory Mediators from Mast Cells" @default.
- W1583622848 doi "https://doi.org/10.1096/fasebj.29.1_supplement.lb82" @default.
- W1583622848 hasPublicationYear "2015" @default.
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