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- W1583631181 abstract "Conflict of interest: none declared. A 62‐year‐old Guyanian woman presented with a 5‐month history of patches on her arms. She worked as a nurse and had a 5‐year history of diffuse idiopathic skeletal hyperostosis (DISH) involving her thoracic spine. On physical examination, erythematous and hyperpigmented patches were seen on the patient’s hands and forearms. There were no other skin changes and no systemic symptoms. On histological examination of a biopsy taken from a lesion, thickening of the dermal collagen and aggregates of lymphocytes around mid and deeper dermal vessels were seen. Laboratory investigations showed that the patient was positive for anti‐nuclear antibodies (1 : 640) and anticentromere antibodies, and negative for double‐stranded DNA antibodies. Routine biochemistry tests and a chest X‐ray gave normal results. The patient was diagnosed with limited scleroderma. Over the next few months she began developing progressive difficulty in swallowing, shortness of breath, further tightening and thickening of the skin on her forearms, dactylitis, and calcinosis. There was involvement of the face with microstomia and beaking of the nose. There were no symptoms of Raynaud disease or dyspepsia reported. The patient was started on oral prednisolone 60 mg/day, and methotrexate was introduced. Several months later, with the patient on 20 mg/week methotrexate, the patches had flattened and the patient’s quality of life had much improved." @default.
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- W1583631181 date "2011-07-20" @default.
- W1583631181 modified "2023-09-23" @default.
- W1583631181 title "Systemic sclerosis in a patient with diffuse idiopathic skeletal hyperostosis" @default.
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- W1583631181 doi "https://doi.org/10.1111/j.1365-2230.2010.03992.x" @default.
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