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- W1583637234 abstract "This chapter discusses several of the new developments, in particular the diversity of BER mechanisms, the regulatory control of BER, and the mutation frequency observed for the BER process for the removal of uracil. One of the major lesions acted upon, by the BER pathway, is uracil. This base is introduced in DNA, by spontaneous deamination of cytosine or by incorporation of deoxyuridine monophosphate (dUMP) during DNA synthesis. Clearly, a uracil introduced opposite any base other than adenine would be a mutagenic event unless corrected and accordingly, a diminished capacity for base excision repair of uracil-modified DNA leads to a mutator phenotype. The chapter discusses the products of the complete BER carried out, by human cell-free extracts on a uracil, specifically, positioned in the M13mp2 plasmid." @default.
- W1583637234 created "2016-06-24" @default.
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- W1583637234 date "2001-01-01" @default.
- W1583637234 modified "2023-09-23" @default.
- W1583637234 title "Session 3 Complexities of BER" @default.
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- W1583637234 doi "https://doi.org/10.1016/s0079-6603(01)68094-2" @default.
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