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- W1583867858 abstract "Youngner, Julius S. (University of Pittsburgh, Pittsburgh, Pa.), and Marion E. Kelly . Inhibition by exogenous interferon of replication of poliovirus ribonucleic acid in chick brain. J. Bacteriol. 90: 443–445. 1965.—The replication of poliovirus was studied after the intracerebral inoculation of infectious ribonucleic acid (RNA) into the brains of 2-day-old chicks; these animals are not susceptible to intact virus. Single-cycle replication of virus, which reached a peak in about 12 hr, was completely inhibited by prior intraperitoneal injection of interferon prepared from the allantoic fluid of chick embryos infected with influenza virus. A single dose of as little as 500 units of interferon, measured by a plaque-reduction method, completely suppressed viral replication when injected 24 hr prior to infectious RNA. This system provides a model for the study of the protection of target organs by passively transferred interferon injected at a distance." @default.
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- W1583867858 date "1965-08-01" @default.
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- W1583867858 title "Inhibition by Exogenous Interferon of Replication of Poliovirus Ribonucleic Acid in Chick Brain" @default.
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- W1583867858 doi "https://doi.org/10.1128/jb.90.2.443-445.1965" @default.
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