Matches in SemOpenAlex for { <https://semopenalex.org/work/W1583972785> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1583972785 endingPage "559" @default.
- W1583972785 startingPage "551" @default.
- W1583972785 abstract "Aim: The aim of this study is to correlate the uptake, residence time, and resulting mean absorbed dose in the kidneys with the posttherapy effect on renal function using the two most commonly used somatostatin analogs, 177Lu-DOTATATE and 177Lu-DOTATOC, during consecutive cycles of peptide receptor radionuclide therapy (PRRNT) in the same patient. Methods: 22 patients with metastatic neuroendocrine tumors underwent PRRNT with 177Lu-DOTATATE and 177Lu-DOTATOC. Dosimetry (MIRD scheme) was performed using OLINDA software. The patients were followed up for 6–12 months with serum creatinine, BUN, tubular extraction rate (TER) using 99mTc-MAG3, and glomerular filtration rate (GFR) using 99mTc-DTPA before and after therapy. Age, hypertension, and diabetes mellitus were the associated risk factors for renal toxicity, which were taken into account. Results: Uptake, residence time, and mean absorbed dose to the kidney were slightly, but significantly, higher for DOTATATE (actual absorbed dose 1.9–9.2 Gy) as compared with DOTATOC (dose 2.3–7.8 Gy) in 19 out of the 22 (86%) patients (p < 0.05). The tumor-to-kidney ratio was higher for DOTATOC in 23 out of 43 (53%) of the lesions analyzed; however, this difference was not statistically significant. There were no statistically significant changes in serum creatinine, BUN, TER or GFR pre and post-therapy with either DOTATATE or DOTATOC. Five of the 22 patients had mildly elevated serum creatinine after PRRNT, of whom 3 had history of hypertension, 1 had diabetes, and 1 was more than 65 years of age. Conclusions: 177Lu-DOTATATE and 177Lu-DOTATOC are safe radiopharmaceuticals concerning renal toxicity. 177Lu-DOTATOC delivers a slightly, but significantly, lower renal dose." @default.
- W1583972785 created "2016-06-24" @default.
- W1583972785 creator A5009383052 @default.
- W1583972785 creator A5051446048 @default.
- W1583972785 creator A5068271017 @default.
- W1583972785 date "2012-08-24" @default.
- W1583972785 modified "2023-10-12" @default.
- W1583972785 title "Peptide Receptor Radionuclide Therapy with 177Lu Labeled Somatostatin Analogs DOTATATE and DOTATOC: Contrasting Renal Dosimetry in the Same Patient" @default.
- W1583972785 cites W1985249499 @default.
- W1583972785 cites W1993872787 @default.
- W1583972785 cites W1994118792 @default.
- W1583972785 cites W1997880280 @default.
- W1583972785 cites W2020347413 @default.
- W1583972785 cites W2031048655 @default.
- W1583972785 cites W2032747682 @default.
- W1583972785 cites W2040531770 @default.
- W1583972785 cites W2047019936 @default.
- W1583972785 cites W2065594133 @default.
- W1583972785 cites W2075600713 @default.
- W1583972785 cites W2098934193 @default.
- W1583972785 cites W2108613323 @default.
- W1583972785 cites W2133962195 @default.
- W1583972785 doi "https://doi.org/10.1007/978-3-642-27994-2_32" @default.
- W1583972785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22918782" @default.
- W1583972785 hasPublicationYear "2012" @default.
- W1583972785 type Work @default.
- W1583972785 sameAs 1583972785 @default.
- W1583972785 citedByCount "17" @default.
- W1583972785 countsByYear W15839727852014 @default.
- W1583972785 countsByYear W15839727852015 @default.
- W1583972785 countsByYear W15839727852016 @default.
- W1583972785 countsByYear W15839727852017 @default.
- W1583972785 countsByYear W15839727852018 @default.
- W1583972785 countsByYear W15839727852021 @default.
- W1583972785 countsByYear W15839727852022 @default.
- W1583972785 countsByYear W15839727852023 @default.
- W1583972785 crossrefType "book-chapter" @default.
- W1583972785 hasAuthorship W1583972785A5009383052 @default.
- W1583972785 hasAuthorship W1583972785A5051446048 @default.
- W1583972785 hasAuthorship W1583972785A5068271017 @default.
- W1583972785 hasConcept C126322002 @default.
- W1583972785 hasConcept C126894567 @default.
- W1583972785 hasConcept C134018914 @default.
- W1583972785 hasConcept C159641895 @default.
- W1583972785 hasConcept C2776297358 @default.
- W1583972785 hasConcept C2780091579 @default.
- W1583972785 hasConcept C2780306776 @default.
- W1583972785 hasConcept C2781025020 @default.
- W1583972785 hasConcept C2989005 @default.
- W1583972785 hasConcept C2993559085 @default.
- W1583972785 hasConcept C71924100 @default.
- W1583972785 hasConcept C75088862 @default.
- W1583972785 hasConcept C80115893 @default.
- W1583972785 hasConceptScore W1583972785C126322002 @default.
- W1583972785 hasConceptScore W1583972785C126894567 @default.
- W1583972785 hasConceptScore W1583972785C134018914 @default.
- W1583972785 hasConceptScore W1583972785C159641895 @default.
- W1583972785 hasConceptScore W1583972785C2776297358 @default.
- W1583972785 hasConceptScore W1583972785C2780091579 @default.
- W1583972785 hasConceptScore W1583972785C2780306776 @default.
- W1583972785 hasConceptScore W1583972785C2781025020 @default.
- W1583972785 hasConceptScore W1583972785C2989005 @default.
- W1583972785 hasConceptScore W1583972785C2993559085 @default.
- W1583972785 hasConceptScore W1583972785C71924100 @default.
- W1583972785 hasConceptScore W1583972785C75088862 @default.
- W1583972785 hasConceptScore W1583972785C80115893 @default.
- W1583972785 hasLocation W15839727851 @default.
- W1583972785 hasLocation W15839727852 @default.
- W1583972785 hasOpenAccess W1583972785 @default.
- W1583972785 hasPrimaryLocation W15839727851 @default.
- W1583972785 hasRelatedWork W136083521 @default.
- W1583972785 hasRelatedWork W1518474861 @default.
- W1583972785 hasRelatedWork W1922636298 @default.
- W1583972785 hasRelatedWork W2006132562 @default.
- W1583972785 hasRelatedWork W2013777072 @default.
- W1583972785 hasRelatedWork W2054956474 @default.
- W1583972785 hasRelatedWork W2065594133 @default.
- W1583972785 hasRelatedWork W2093693472 @default.
- W1583972785 hasRelatedWork W2131979641 @default.
- W1583972785 hasRelatedWork W2151397963 @default.
- W1583972785 isParatext "false" @default.
- W1583972785 isRetracted "false" @default.
- W1583972785 magId "1583972785" @default.
- W1583972785 workType "book-chapter" @default.