FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1583989983> ?p ?o ?g. }

• W1583989983 endingPage "9" @default.
• W1583989983 startingPage "733" @default.
• W1583989983 abstract "Recombinant human erythropoietin (rhEPO) at pharmacological doses was used to improve anemia and reduce the transfusional requirements of 43 patients with myelodysplastic syndrome (MDS). rhEPO was given by s.c. injection three times per week for 12 weeks. The EPO dose was started at 150 IU/kg and was increased to 300 IU/kg if after 6 weeks there was no or suboptimal erythroid response. Responses were defined as being a complete response (CR), partial response (PR), or no response (NR). A CR was considered a rise in untransfused hemoglobin concentrations of at least 2 g/dl or a 100% decrease in RBC transfusion requirements over the treatment period. A PR was defined as an increase in untransfused hemoglobin values of 1-2 g/dl or a decrease in RBC transfusion requirements equal to or greater than 50%. NR was defined as responses less than a PR. Patients who responded to therapy were continued on rhEPO at the same dose for 6 additional months. An objective response (CR and PR) was observed in 7 of 42 (16.7%) assessable cases after 6 weeks of treatment at the dose of 150 IU/kg. Dose escalation (300 IU/kg) in nonresponders resulted in another six patients attaining a rise in hemoglobin concentrations. The final response rate was 13 of 41 (31.7%); 4 patients became transfusion independent. Therapy was tolerated well, with no relevant side effects. MDS progression was seen in one case. An elevated bone marrow erythroid infiltration (erythroid index) and detectable pretreatment circulating erythroid progenitors (burst-forming units-erythroid) were the best predictors of hemoglobin response when we controlled for other variables. These data suggest that rhEPO has a role in the treatment of certain patients with MDS, particularly in those with a high erythroid index and detectable circulating erythroid burst-forming units." @default.
• W1583989983 created "2016-06-24" @default.
• W1583989983 creator A5003087147 @default.
• W1583989983 creator A5021162104 @default.
• W1583989983 creator A5022313226 @default.
• W1583989983 creator A5025381371 @default.
• W1583989983 creator A5032457984 @default.
• W1583989983 creator A5052848620 @default.
• W1583989983 creator A5054462127 @default.
• W1583989983 creator A5069105192 @default.
• W1583989983 creator A5083151156 @default.
• W1583989983 date "1997-05-01" @default.
• W1583989983 modified "2023-10-14" @default.
• W1583989983 title "Response to recombinant human erythropoietin in patients with myelodysplastic syndromes." @default.
• W1583989983 cites W1969313253 @default.
• W1583989983 cites W1976278378 @default.
• W1583989983 cites W1979820704 @default.
• W1583989983 cites W1993317268 @default.
• W1583989983 cites W1993642530 @default.
• W1583989983 cites W1993662394 @default.
• W1583989983 cites W2026452824 @default.
• W1583989983 cites W2028295142 @default.
• W1583989983 cites W2044823907 @default.
• W1583989983 cites W2056555300 @default.
• W1583989983 cites W2085622873 @default.
• W1583989983 cites W2094744588 @default.
• W1583989983 cites W2107357720 @default.
• W1583989983 cites W2131651077 @default.
• W1583989983 cites W2154037033 @default.
• W1583989983 cites W2167805334 @default.
• W1583989983 cites W2279904850 @default.
• W1583989983 cites W2354458613 @default.
• W1583989983 cites W2413515934 @default.
• W1583989983 cites W2419384495 @default.
• W1583989983 cites W1983392832 @default.
• W1583989983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9815743" @default.
• W1583989983 hasPublicationYear "1997" @default.
• W1583989983 type Work @default.
• W1583989983 sameAs 1583989983 @default.
• W1583989983 citedByCount "7" @default.
• W1583989983 crossrefType "journal-article" @default.
• W1583989983 hasAuthorship W1583989983A5003087147 @default.
• W1583989983 hasAuthorship W1583989983A5021162104 @default.
• W1583989983 hasAuthorship W1583989983A5022313226 @default.
• W1583989983 hasAuthorship W1583989983A5025381371 @default.
• W1583989983 hasAuthorship W1583989983A5032457984 @default.
• W1583989983 hasAuthorship W1583989983A5052848620 @default.
• W1583989983 hasAuthorship W1583989983A5054462127 @default.
• W1583989983 hasAuthorship W1583989983A5069105192 @default.
• W1583989983 hasAuthorship W1583989983A5083151156 @default.
• W1583989983 hasConcept C126322002 @default.
• W1583989983 hasConcept C141071460 @default.
• W1583989983 hasConcept C203014093 @default.
• W1583989983 hasConcept C2778248108 @default.
• W1583989983 hasConcept C2778534260 @default.
• W1583989983 hasConcept C2778917026 @default.
• W1583989983 hasConcept C2779703530 @default.
• W1583989983 hasConcept C2780007613 @default.
• W1583989983 hasConcept C2780817109 @default.
• W1583989983 hasConcept C71924100 @default.
• W1583989983 hasConcept C90924648 @default.
• W1583989983 hasConceptScore W1583989983C126322002 @default.
• W1583989983 hasConceptScore W1583989983C141071460 @default.
• W1583989983 hasConceptScore W1583989983C203014093 @default.
• W1583989983 hasConceptScore W1583989983C2778248108 @default.
• W1583989983 hasConceptScore W1583989983C2778534260 @default.
• W1583989983 hasConceptScore W1583989983C2778917026 @default.
• W1583989983 hasConceptScore W1583989983C2779703530 @default.
• W1583989983 hasConceptScore W1583989983C2780007613 @default.
• W1583989983 hasConceptScore W1583989983C2780817109 @default.
• W1583989983 hasConceptScore W1583989983C71924100 @default.
• W1583989983 hasConceptScore W1583989983C90924648 @default.
• W1583989983 hasIssue "5" @default.
• W1583989983 hasLocation W15839899831 @default.
• W1583989983 hasOpenAccess W1583989983 @default.
• W1583989983 hasPrimaryLocation W15839899831 @default.
• W1583989983 hasRelatedWork W1583989983 @default.
• W1583989983 hasRelatedWork W1994147186 @default.
• W1583989983 hasRelatedWork W2004226158 @default.
• W1583989983 hasRelatedWork W2094744588 @default.
• W1583989983 hasRelatedWork W2131651077 @default.
• W1583989983 hasRelatedWork W2361222070 @default.
• W1583989983 hasRelatedWork W2398344314 @default.
• W1583989983 hasRelatedWork W2415006319 @default.
• W1583989983 hasRelatedWork W2554900558 @default.
• W1583989983 hasRelatedWork W2559192146 @default.
• W1583989983 hasVolume "3" @default.
• W1583989983 isParatext "false" @default.
• W1583989983 isRetracted "false" @default.
• W1583989983 magId "1583989983" @default.
• W1583989983 workType "article" @default.