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• W1584006299 abstract "Background . WHO’s recommendation of<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:msub><mml:mrow><mml:mtext>HbA</mml:mtext></mml:mrow><mml:mrow><mml:mtext>1c</mml:mtext></mml:mrow></mml:msub><mml:mo>≥</mml:mo><mml:mn>48</mml:mn></mml:math> mmol/mol (6.5%) as diagnostic for type 2 diabetes mellitus (T2DM) was adopted by three UK London boroughs in May 2012. The South London Diabetes (SOUL-D) study has recruited people with newly diagnosed T2DM since 2008. We compared participants diagnosed before May 2012 with<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:msub><mml:mrow><mml:mtext>HbA</mml:mtext></mml:mrow><mml:mrow><mml:mtext>1c</mml:mtext></mml:mrow></mml:msub><mml:mo><</mml:mo><mml:mn>48</mml:mn></mml:math> mmol/mol to those with diagnostic<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:msub><mml:mrow><mml:mtext>HbA</mml:mtext></mml:mrow><mml:mrow><mml:mtext>1c</mml:mtext></mml:mrow></mml:msub><mml:mo>≥</mml:mo><mml:mn>48</mml:mn></mml:math> mmol/mol. Methods . A prospective cohort study of newly diagnosed T2DM participants from 96 primary care practices, comparing demographic and biomedical variables between those with diagnostic<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:msub><mml:mrow><mml:mtext>HbA</mml:mtext></mml:mrow><mml:mrow><mml:mtext>1c</mml:mtext></mml:mrow></mml:msub><mml:mo><</mml:mo><mml:mn>48</mml:mn></mml:math> mmol/mol or<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:msub><mml:mrow><mml:mtext>HbA</mml:mtext></mml:mrow><mml:mrow><mml:mtext>1c</mml:mtext></mml:mrow></mml:msub><mml:mo>≥</mml:mo><mml:mn>48</mml:mn></mml:math> mmol/mol at recruitment and after one year. Results . Of 1488 participants, 22.8% had diagnostic<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:msub><mml:mrow><mml:mtext>HbA</mml:mtext></mml:mrow><mml:mrow><mml:mtext>1c</mml:mtext></mml:mrow></mml:msub><mml:mo><</mml:mo><mml:mn>48</mml:mn></mml:math> mmol/mol. They were older and more likely to be white (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:math>). At recruitment and one year, there were no between-group differences in the prevalence of diabetic complications, except that those diagnosed with<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:msub><mml:mrow><mml:mtext>HbA</mml:mtext></mml:mrow><mml:mrow><mml:mtext>1c</mml:mtext></mml:mrow></mml:msub><mml:mo><</mml:mo><mml:mn>48</mml:mn></mml:math> mmol/mol had more sensory neuropathy at recruitment (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.039</mml:mn></mml:math>) and, at one year, had new myocardial infarction (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M10><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.012</mml:mn></mml:math>) but less microalbuminuria (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M11><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.012</mml:mn></mml:math>). Conclusions . Use of<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M12><mml:msub><mml:mrow><mml:mtext>HbA</mml:mtext></mml:mrow><mml:mrow><mml:mtext>1c</mml:mtext></mml:mrow></mml:msub><mml:mo>≥</mml:mo><mml:mn>48</mml:mn></mml:math> mmol/mol as the sole T2DM diagnostic criterion may miss almost a quarter of those previously diagnosed in South London yet<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M13><mml:msub><mml:mrow><mml:mtext>HbA</mml:mtext></mml:mrow><mml:mrow><mml:mtext>1c</mml:mtext></mml:mrow></mml:msub><mml:mo><</mml:mo><mml:mn>48</mml:mn></mml:math> mmol/mol may not exclude clinically important diabetes." @default.
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• W1584006299 date "2015-01-01" @default.
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• W1584006299 title "Diabetes Complications at Presentation and One Year by Glycated Haemoglobin at Diagnosis in a Multiethnic and Diverse Socioeconomic Population: Results from the South London Diabetes Study" @default.
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