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• W158403930 abstract "1749 Objectives: FDDNP PET has been shown to be able to distinguish patients with Alzheimer’s disease (AD) from normal subjects. In this project we use brain cortical surface map to examine the rate of change in FDDNP distribution volume (DVR) in the progression of AD. Cortical surface map of PET images provides a standardized space that allows easy inter-subject comparison and for 3D visualization while retaining the quantitative aspect of PET. In this study, we examined the FDDNP DVR changes versus a common behavior score, MMSE. Effect of partial volume on cortical maps of FDDNP was also examined. Methods: Images from 23 subjects (with 7 AD) were studied. Logan graphical plots were used with the cerebellum as reference region to generate the DVR image of FDDNP. Affine transformation was applied to the MRI to put it into ICBM space. A hemispheric cortical surface model for each subject was extracted from the MRI in ICBM space. The same transformations were applied to the DVR images to put them into the same cortical space. For partial volume correction (PVC), a simulated PET was created from a mask based on the MR derived cortical surface. This image was smoothed to the PET resolution and mapped to the cortical surface to generate a surface map of the simulated PET. The cortical map with PVC was calculated as the ratio of the DVR cortical surface and that of the simulated PET. Linear regression was used to assess the rate of change of DVR vs MMSE for each point on the hemispheric cortical surface. Results: Without PVC, DVR values on the lateral surface were significantly lower than 1.0 and were lower than on the medical surface. After PVC, DVR on the lateral surface was raised to values expected from original 3D DVR image; values on medial side were no longer higher than on the lateral surface. Rate of change vs MMSE was found to be about 0.02 in the frontal and temporal regions especially in the left brain hemisphere. Conclusions: Hemispheric cortical surface mapping is useful for assessing and visualizing the rate of change of DVR vs behavior scores. PVC is important to preserve the quantitative nature of the DVR values on the cortical surface map. Research Support (if any): DOE contract DE-FC03-87-ER60615" @default.
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• W158403930 date "2007-05-01" @default.
• W158403930 modified "2023-09-23" @default.
• W158403930 title "Hemispheric cortical surface map for assessing the rate of changes of regional cortical FDDNP distribution volume versus MMSE score" @default.
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