Matches in SemOpenAlex for { <https://semopenalex.org/work/W1584069905> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1584069905 startingPage "4542" @default.
- W1584069905 abstract "Epidermal Growth Factor Receptor (EGFR) pathway activation is a frequent event in human lung cancer with over-expression one of the earliest abnormalities in the bronchial epithelium of smokers and present in all stages of preinvasive cancer. Mutations in EGFR itself are rare and the mechanisms regulating EGFR pathway activation remained elusive. Leucine-rich immunoglobulin repeats-1 (LRIG1), an inhibitor of EGFR activity, is one of 4 genes identified that predict patient survival across solid tumor types. We hypothesize that tissue homeostasis is maintained via strong endogenous regulation of EGFR signaling by the inhibitor LRIG1 and its loss is the key step in the initiation of preinvasive lung disease. Our experiments show that deletion of LRIG1 is sufficient to promote murine airway hyperplasia. In vitro, LRIG1 deficient cells display loss of contact inhibition, whereas re-expression of LRIG1 in human lung cancer cell lines impairs growth. We find that LRIG1 forms a ternary complex with EGFR and E-Cadherin at the cell surface. This complex modulates the activity of the EGFR and downstream pathways. We also show that loss of heterozygosity at the LRIG1 locus as well as down-regulation of LRIG1 gene expression are early events in the development of preinvasive human squamous lung cancer. Our findings imply that lung cancer development is driven by a change in the amplitude of EGFR signaling governed by the loss of contact inhibition." @default.
- W1584069905 created "2016-06-24" @default.
- W1584069905 creator A5017133007 @default.
- W1584069905 creator A5024999460 @default.
- W1584069905 creator A5038131018 @default.
- W1584069905 creator A5038725960 @default.
- W1584069905 creator A5049207432 @default.
- W1584069905 creator A5052074418 @default.
- W1584069905 creator A5061727235 @default.
- W1584069905 creator A5068471552 @default.
- W1584069905 creator A5073876921 @default.
- W1584069905 creator A5074541789 @default.
- W1584069905 creator A5081286663 @default.
- W1584069905 date "2012-09-01" @default.
- W1584069905 modified "2023-09-26" @default.
- W1584069905 title "LSC 2012 abstract - LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and preinvasive squamous cell carcinoma development" @default.
- W1584069905 hasPublicationYear "2012" @default.
- W1584069905 type Work @default.
- W1584069905 sameAs 1584069905 @default.
- W1584069905 citedByCount "0" @default.
- W1584069905 crossrefType "journal-article" @default.
- W1584069905 hasAuthorship W1584069905A5017133007 @default.
- W1584069905 hasAuthorship W1584069905A5024999460 @default.
- W1584069905 hasAuthorship W1584069905A5038131018 @default.
- W1584069905 hasAuthorship W1584069905A5038725960 @default.
- W1584069905 hasAuthorship W1584069905A5049207432 @default.
- W1584069905 hasAuthorship W1584069905A5052074418 @default.
- W1584069905 hasAuthorship W1584069905A5061727235 @default.
- W1584069905 hasAuthorship W1584069905A5068471552 @default.
- W1584069905 hasAuthorship W1584069905A5073876921 @default.
- W1584069905 hasAuthorship W1584069905A5074541789 @default.
- W1584069905 hasAuthorship W1584069905A5081286663 @default.
- W1584069905 hasConcept C121608353 @default.
- W1584069905 hasConcept C126322002 @default.
- W1584069905 hasConcept C142724271 @default.
- W1584069905 hasConcept C2776256026 @default.
- W1584069905 hasConcept C2779438470 @default.
- W1584069905 hasConcept C502942594 @default.
- W1584069905 hasConcept C54355233 @default.
- W1584069905 hasConcept C62112901 @default.
- W1584069905 hasConcept C64979461 @default.
- W1584069905 hasConcept C71924100 @default.
- W1584069905 hasConcept C86803240 @default.
- W1584069905 hasConcept C95444343 @default.
- W1584069905 hasConceptScore W1584069905C121608353 @default.
- W1584069905 hasConceptScore W1584069905C126322002 @default.
- W1584069905 hasConceptScore W1584069905C142724271 @default.
- W1584069905 hasConceptScore W1584069905C2776256026 @default.
- W1584069905 hasConceptScore W1584069905C2779438470 @default.
- W1584069905 hasConceptScore W1584069905C502942594 @default.
- W1584069905 hasConceptScore W1584069905C54355233 @default.
- W1584069905 hasConceptScore W1584069905C62112901 @default.
- W1584069905 hasConceptScore W1584069905C64979461 @default.
- W1584069905 hasConceptScore W1584069905C71924100 @default.
- W1584069905 hasConceptScore W1584069905C86803240 @default.
- W1584069905 hasConceptScore W1584069905C95444343 @default.
- W1584069905 hasLocation W15840699051 @default.
- W1584069905 hasOpenAccess W1584069905 @default.
- W1584069905 hasPrimaryLocation W15840699051 @default.
- W1584069905 hasRelatedWork W1537760130 @default.
- W1584069905 hasRelatedWork W1560447611 @default.
- W1584069905 hasRelatedWork W1920765900 @default.
- W1584069905 hasRelatedWork W1984235695 @default.
- W1584069905 hasRelatedWork W2002918138 @default.
- W1584069905 hasRelatedWork W2032665459 @default.
- W1584069905 hasRelatedWork W2037041091 @default.
- W1584069905 hasRelatedWork W2088597129 @default.
- W1584069905 hasRelatedWork W2137899535 @default.
- W1584069905 hasRelatedWork W2163974863 @default.
- W1584069905 hasRelatedWork W2168486358 @default.
- W1584069905 hasRelatedWork W2517609385 @default.
- W1584069905 hasRelatedWork W2625660736 @default.
- W1584069905 hasRelatedWork W2884033128 @default.
- W1584069905 hasRelatedWork W2902155985 @default.
- W1584069905 hasRelatedWork W2971353960 @default.
- W1584069905 hasRelatedWork W3001531511 @default.
- W1584069905 hasRelatedWork W3139579456 @default.
- W1584069905 hasRelatedWork W46404346 @default.
- W1584069905 hasRelatedWork W3207592613 @default.
- W1584069905 hasVolume "40" @default.
- W1584069905 isParatext "false" @default.
- W1584069905 isRetracted "false" @default.
- W1584069905 magId "1584069905" @default.
- W1584069905 workType "article" @default.