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- W158409743 abstract "Stoppage of endurance exercise training leads to complete loss of V̇O2 max gain but not submaximal and maximal exercise blood lactate concentrations. However, the detailed mechanisms are still unknown because the transcriptome of skeletal muscle after detraining has never been characterized. Thus, we investigated the effects of exercise-training cessation at lactate threshold (LT) intensity on physiological adaptations and skeletal muscle transcriptome. Twelve weeks of detraining abolished the effect of 12-weeks LT training on V̇O2 max. The detraining also reversed V̇O2 at LT intensity, however, the value tended to be higher than the pre-training level (p = 0.07). Moreover, the training cessation did not affect the number of capillaries around type I fiber which was increased by the LT training. The global gene expression profile measured by serial analysis of gene expression (SAGE) revealed that the training and detraining modulated 249 and 245 characterized transcripts, respectively. The majority of training-responsive transcripts (86%) showed a significant reversible effect of detraining. However, the most-induced transcripts by the training were still elevated after the same period of detraining. These genes are involved in oxygen transport, creatine and mitochondrial energy metabolisms, contractile apparatus, and protein synthesis. Incomplete reversal of these transcripts as well as sustained capillary distribution by the detraining may contribute to the partial reversal of V̇O2 at LT intensity." @default.
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- W158409743 date "2007-01-01" @default.
- W158409743 modified "2023-09-26" @default.
- W158409743 title "The effects of mild‐exercise training cessation on physiological adaptations and gene expressions in human skeletal muscle" @default.
- W158409743 doi "https://doi.org/10.1096/fasebj.21.6.lb106-a" @default.
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