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- W1584116092 endingPage "1813" @default.
- W1584116092 startingPage "1807" @default.
- W1584116092 abstract "Development of naive T cells into type 1 (Th1, Tc1) or type 2 (Th2, Tc2) effector cells is thought to be under the control of cytokines. In this study, we show that when both IL-12 and IL-4 are present, murine and human T cell differentiation is regulated by the balance of protein kinase C (PKC) and calcium signaling within T cells. Although both biochemical signals were required for T cell activation via the TCR, altering the balance between them redirected type 1 cells to type 2 and vice versa. Stimulation of calcium signaling or inhibition of PKC favored type 1 differentiation, whereas stimulation of PKC or inhibition of calcineurin resulted in type 2 effectors. Altered peptide ligands induced distinct balances of PKC/calcium signaling and altered Tc1/Tc2 development in TCR-transgenic CD8 T cells. The data suggest novel strategies for manipulation of the immune response in vivo." @default.
- W1584116092 created "2016-06-24" @default.
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- W1584116092 date "2000-02-15" @default.
- W1584116092 modified "2023-10-14" @default.
- W1584116092 title "The Balance of Protein Kinase C and Calcium Signaling Directs T Cell Subset Development" @default.
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- W1584116092 doi "https://doi.org/10.4049/jimmunol.164.4.1807" @default.
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