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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1584203472> ?p ?o ?g. }

• W1584203472 endingPage "5330" @default.
• W1584203472 startingPage "5327" @default.
• W1584203472 abstract "Mouse spleen contains three distinct mature dendritic cell (DC) populations (CD4(+)8(-), CD4(-)8(-), and CD4(-)8(+)) which retain a capacity to take up particulate and soluble AGS: Although the three splenic DC subtypes showed similar uptake of injected soluble OVA, they differed markedly in their capacity to present this Ag and activate proliferation in OVA-specific CD4 or CD8 T cells. For class II MHC-restricted presentation to CD4 T cells, the CD8(-) DC subtypes were more efficient, but for class I MHC-restricted presentation to CD8 T cells, the CD8(+) DC subtype was far more effective. This differential persisted when the DC were activated with LPS. The CD8(+) DC are therefore specialized for in vivo cross-presentation of exogenous soluble Ags into the class I MHC presentation pathway." @default.
• W1584203472 created "2016-06-24" @default.
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• W1584203472 date "2001-05-01" @default.
• W1584203472 modified "2023-10-14" @default.
• W1584203472 title "Cutting Edge: Intravenous Soluble Antigen Is Presented to CD4 T Cells by CD8− Dendritic Cells, but Cross-Presented to CD8 T Cells by CD8+ Dendritic Cells" @default.
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• W1584203472 doi "https://doi.org/10.4049/jimmunol.166.9.5327" @default.
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